Renoprotective approaches and strategies in acute kidney injury

Yuan Yang, Meifang Song, Yu Liu, Hong Liu, Lin Sun, Youming Peng, Fuyou Liu, Manjeri A. Venkatachalam, Zheng Dong

Resultado de la investigación: Review articlerevisión exhaustiva

84 Citas (Scopus)


Acute kidney injury (AKI) is a major renal disease associated with high mortality rate and increasing prevalence. Decades of research have suggested numerous chemical and biological agents with beneficial effects in AKI. In addition, cell therapy and molecular targeting have been explored for reducing kidney tissue damage and promoting kidney repair or recovery from AKI. Mechanistically, these approaches may mitigate oxidative stress, inflammation, cell death, and mitochondrial and other organellar damage, or activate cytoprotective mechanisms such as autophagy and pro-survival factors. However, none of these findings has been successfully translated into clinical treatment of AKI. In this review, we analyze these findings and propose experimental strategies for the identification of renoprotective agents or methods with clinical potential. Moreover, we propose the consideration of combination therapy by targeting multiple targets in AKI.

Idioma originalEnglish (US)
Páginas (desde-hasta)58-73
Número de páginas16
PublicaciónPharmacology and Therapeutics
EstadoPublished - jul 1 2016

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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