Relationship of Movements and Behaviors to Group A Streptococcus Infections in Elementary School Children

Tanya K. Murphy, Lisa A. Snider, P. Jane Mutch, Elaine Harden, Annette Zaytoun, Paula J. Edge, Eric A. Storch, Mark C.K. Yang, Giselle Mann, Wayne K. Goodman, Susan E. Swedo

Producción científica: Articlerevisión exhaustiva

58 Citas (Scopus)

Resumen

Background: Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus (PANDAS) research is based on the hypothesis that infections trigger changes in behavior and movement in children. Methods: We enrolled 693 children (ages 3 to 12 years) into a systematic, longitudinal study. Data were collected monthly for 8 months (October-May) to determine point prevalence of Group A Streptococcal (GAS) infections, tics, behavior, and choreiform movements. Simultaneous throat cultures were obtained, and relational analyses were made between GAS and movement/observation ratings. Results: Combined behavior/GAS associations (concurrent with or 3 subsequent months to GAS) revealed a strong relationship, relative risk (RR) of 1.71 (p < .0001). Detailed analysis revealed that balance/swaying and non-tic grimacing were responsible for a significant proportion of this association (RR = 2.92, p < .0001). A strong seasonal pattern was found, with fall being more significant for GAS infections and observation ratings (p < .0001) compared with winter/spring. Children with repeated streptococcus (n = 64) showed higher rates of behavior and distal choreiform observations (p = .005). Conclusions: Motor/behavior changes were noted to occur in relationship to positive GAS culture with support that repeated GAS increases risk.

Idioma originalEnglish (US)
Páginas (desde-hasta)279-284
Número de páginas6
PublicaciónBiological Psychiatry
Volumen61
N.º3
DOI
EstadoPublished - feb 1 2007
Publicado de forma externa

ASJC Scopus subject areas

  • Biological Psychiatry

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