@article{de8542f5b6104068976c5f107ea105b4,
title = "Relations of mitochondrial genetic variants to measures of vascular function",
abstract = "Mitochondrial genetic variation with resultant alterations in oxidative phosphorylation may influence vascular function and contribute to cardiovascular disease susceptibility. We assessed relations of peptide-encoding variants in the mitochondrial genome with measures of vascular function in Framingham Heart Study participants. Of 258 variants assessed, 40 were predicted to have functional consequences by bioinformatics programs. A maternal pattern of heritability was estimated to contribute to the variability of aortic stiffness. A putative association with a microvascular function measure was identified that requires replication. The methods we have developed can be applied to assess the relations of mitochondrial genetic variation to other phenotypes.",
keywords = "Mitochondrial genetics, Vascular function",
author = "Fetterman, {Jessica L.} and Chunyu Liu and Mitchell, {Gary F.} and Vasan, {Ramachandran S.} and Benjamin, {Emelia J.} and Vita, {Joseph A.} and Hamburg, {Naomi M.} and Daniel Levy",
note = "Funding Information: This work was supported by the National Heart Lung and Blood Institute (NHLBI) contracts [N01-HC-25195, HHSN268201500001I, R.S. Vasan], NHLBI grant [R01-DK-080739, R.S. Vasan], NHLBI grants [R01-HL-107385, R01-HL-126136, R.S. Vasan and G.F. Mitchell], NHLBI grants [1R01-HL-60040, 1R01-HL-70100, 1R01-HL-128914, 2R01-HL092577, E.J. Benjamin], and NIH grants [R01-HL102299, R01-HL109790, N.M. Hamburg]. Funding for this project was also provided by the Division of Intramural Research of the National Heart, Lung, and Blood Institute (D. Levy and C. Liu). Funding Information: This work was supported by the National Heart Lung and Blood Institute (NHLBI) contracts [ N01-HC-25195 , HHSN268201500001I , R.S. Vasan], NHLBI grant [ R01-DK-080739 , R.S. Vasan], NHLBI grants [ R01-HL-107385 , R01-HL-126136 , R.S. Vasan and G.F. Mitchell], NHLBI grants [ 1R01-HL-60040 , 1R01-HL-70100 , 1R01-HL-128914 , 2R01-HL092577 , E.J. Benjamin], and NIH grants [ R01-HL102299 , R01-HL109790 , N.M. Hamburg]. Funding for this project was also provided by the Division of Intramural Research of the National Heart, Lung, and Blood Institute (D. Levy and C. Liu). Publisher Copyright: {\textcopyright} 2017 Elsevier B.V. and Mitochondria Research Society",
year = "2018",
month = may,
doi = "10.1016/j.mito.2017.10.001",
language = "English (US)",
volume = "40",
pages = "51--57",
journal = "Mitochondrion",
issn = "1567-7249",
publisher = "Elsevier",
}