TY - JOUR
T1 - Relations of circulating GDF-15, soluble ST2, and troponin-I concentrations with vascular function in the community
T2 - The Framingham Heart Study
AU - Andersson, Charlotte
AU - Enserro, Danielle
AU - Sullivan, Lisa
AU - Wang, Thomas J.
AU - Januzzi, James L.
AU - Benjamin, Emelia J.
AU - Vita, Joseph A.
AU - Hamburg, Naomi M.
AU - Larson, Martin G.
AU - Mitchell, Gary F.
AU - Vasan, Ramachandran S.
N1 - Funding Information:
This study was funded by the NIH Heart, Lung and Blood Institute (Contract #N01-HC-25195 , and R01 HL107385 , PI Vasan) and ( 1R01HL60040 ; 1RO1HL70100 ) with additional support from Evans Scholar award from the department of Medicine, Boston University School of Medicine (PI, Vasan). Dr. Januzzi is supported in part by the Desanctis Clinical Scholar Endowment and the Hutter Family Professorship . Dr. Andersson was supported by a grant from the Danish Research Council .
Publisher Copyright:
© 2016 Elsevier Ireland Ltd.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Background and aims: Growth differentiation factor-15 (GDF-15), soluble (s)ST2, and high-sensitivity troponin-I (hs-TnI) are associated with incident cardiovascular disease (CVD) including heart failure, yet the underlying mechanisms are not fully understood. We investigated if GDF-15, sST2, and hs-TnI are related to subclinical vascular dysfunction in the community, which may explain the relations of these biomarkers with CVD. Methods: We evaluated 1823 Framingham Study participants (mean age 61 ± 10 years, 54% women) who underwent routine assessment of vascular function. We related circulating GDF-15, sST2, and hs-TnI concentrations to measures of arterial stiffness (carotid-femoral pulse wave velocity, CFPWV; augmentation index; and forward pressure wave amplitude, FW), endothelial-dependent vasodilation (flow-mediated dilation, FMD), and baseline and hyperemic brachial flow velocities using linear regression adjusting for standard risk factors. Results: After multivariable adjustment, GDF-15 levels were positively associated with CFPWV (0.044 [95% confidence interval 0.007-0.081] standard deviation [SD] change per SD increase in loge[GDF-15], p = 0.02) and FW (0.076 [0.026-0.126] SD change per SD increase in loge[GDF-15], p = 0.003) and inversely related to FMD (-0.051 [-0.101-0.0003] SD change per SD increase in loge[GDF-15], p = 0.048). sST2 was positively associated with CFPWV (0.032 [0.0005-0.063] SD change per SD increase in loge[sST2], p = 0.046), and hs-TnI inversely associated with hyperemic flow velocity (-0.041 [-0.082-0.0004] SD change per SD increase in loge[hs-TnI], p = 0.048). Conclusion: In our community-based investigation, individual cardiac stress biomarkers were differentially related to select aspects of vascular function. These findings may contribute to the associations of circulating GDF-15, sST2, and hs-TnI with incident CVD and heart failure.
AB - Background and aims: Growth differentiation factor-15 (GDF-15), soluble (s)ST2, and high-sensitivity troponin-I (hs-TnI) are associated with incident cardiovascular disease (CVD) including heart failure, yet the underlying mechanisms are not fully understood. We investigated if GDF-15, sST2, and hs-TnI are related to subclinical vascular dysfunction in the community, which may explain the relations of these biomarkers with CVD. Methods: We evaluated 1823 Framingham Study participants (mean age 61 ± 10 years, 54% women) who underwent routine assessment of vascular function. We related circulating GDF-15, sST2, and hs-TnI concentrations to measures of arterial stiffness (carotid-femoral pulse wave velocity, CFPWV; augmentation index; and forward pressure wave amplitude, FW), endothelial-dependent vasodilation (flow-mediated dilation, FMD), and baseline and hyperemic brachial flow velocities using linear regression adjusting for standard risk factors. Results: After multivariable adjustment, GDF-15 levels were positively associated with CFPWV (0.044 [95% confidence interval 0.007-0.081] standard deviation [SD] change per SD increase in loge[GDF-15], p = 0.02) and FW (0.076 [0.026-0.126] SD change per SD increase in loge[GDF-15], p = 0.003) and inversely related to FMD (-0.051 [-0.101-0.0003] SD change per SD increase in loge[GDF-15], p = 0.048). sST2 was positively associated with CFPWV (0.032 [0.0005-0.063] SD change per SD increase in loge[sST2], p = 0.046), and hs-TnI inversely associated with hyperemic flow velocity (-0.041 [-0.082-0.0004] SD change per SD increase in loge[hs-TnI], p = 0.048). Conclusion: In our community-based investigation, individual cardiac stress biomarkers were differentially related to select aspects of vascular function. These findings may contribute to the associations of circulating GDF-15, sST2, and hs-TnI with incident CVD and heart failure.
KW - Biomarkers
KW - Endothelial function
KW - GDF-15
KW - General population
KW - ST2
KW - Troponin I
KW - Vascular stiffness
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U2 - 10.1016/j.atherosclerosis.2016.02.013
DO - 10.1016/j.atherosclerosis.2016.02.013
M3 - Article
C2 - 26972631
AN - SCOPUS:84959876023
SN - 0021-9150
VL - 248
SP - 245
EP - 251
JO - Atherosclerosis
JF - Atherosclerosis
ER -