Regulation of Transforming Growth Factor β in Diabetic Nephropathy: Implications for Treatment

Yanqing Zhu; Hitomi Kataoka Usui; Kumar Sharma

doi:10.1016/j.semnephrol.2007.01.008

Regulation of Transforming Growth Factor β in Diabetic Nephropathy: Implications for Treatment

Yanqing Zhu, Hitomi Kataoka Usui, Kumar Sharma

Resultado de la investigación: Article › revisión exhaustiva

85 Citas (Scopus)

Resumen

Summary: The recognition that the drivers of matrix accumulation is an appropriate therapeutic target for diabetic nephropathy is now accepted by the nephrology and pharmaceutical communities. Interventions focused around transforming growth factor-β (TGF-β) likely will be an important area of clinical investigation in the near future. Understanding the various pathways involved in stimulating TGF-β in the diabetic kidney is of paramount importance in devising strategies to combat the development and progression of diabetic nephropathy. In this review we highlight the major pathways involved in stimulating TGF-β production by increased glucose levels and discuss the therapeutic implications thereof.

Idioma original	English (US)
Páginas (desde-hasta)	153-160
Número de páginas	8
Publicación	Seminars in nephrology
Volumen	27
N.º	2
DOI	https://doi.org/10.1016/j.semnephrol.2007.01.008
Estado	Published - mar 2007
Publicado de forma externa	Sí

ASJC Scopus subject areas

Nephrology

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10.1016/j.semnephrol.2007.01.008

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title = "Regulation of Transforming Growth Factor β in Diabetic Nephropathy: Implications for Treatment",

abstract = "Summary: The recognition that the drivers of matrix accumulation is an appropriate therapeutic target for diabetic nephropathy is now accepted by the nephrology and pharmaceutical communities. Interventions focused around transforming growth factor-β (TGF-β) likely will be an important area of clinical investigation in the near future. Understanding the various pathways involved in stimulating TGF-β in the diabetic kidney is of paramount importance in devising strategies to combat the development and progression of diabetic nephropathy. In this review we highlight the major pathways involved in stimulating TGF-β production by increased glucose levels and discuss the therapeutic implications thereof.",

keywords = "HETE, Protein kinase C, decorin, glucose excursion, macrophages, podocytes, reactive oxygen species, thrombospondin, upstream stimulatory factor",

author = "Yanqing Zhu and Usui, {Hitomi Kataoka} and Kumar Sharma",

note = "Funding Information: Supported by the National Institutes of Health (R01DK053867-07, R01DK063017-04, U01DK076133-02 to K.S.), the American Diabetes Association, and the Juvenile Diabetes Research Foundation. ",

year = "2007",

month = mar,

doi = "10.1016/j.semnephrol.2007.01.008",

language = "English (US)",

volume = "27",

pages = "153--160",

journal = "Seminars in Nephrology",

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publisher = "W.B. Saunders Ltd",

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T1 - Regulation of Transforming Growth Factor β in Diabetic Nephropathy

T2 - Implications for Treatment

AU - Zhu, Yanqing

AU - Usui, Hitomi Kataoka

AU - Sharma, Kumar

N1 - Funding Information: Supported by the National Institutes of Health (R01DK053867-07, R01DK063017-04, U01DK076133-02 to K.S.), the American Diabetes Association, and the Juvenile Diabetes Research Foundation.

PY - 2007/3

Y1 - 2007/3

N2 - Summary: The recognition that the drivers of matrix accumulation is an appropriate therapeutic target for diabetic nephropathy is now accepted by the nephrology and pharmaceutical communities. Interventions focused around transforming growth factor-β (TGF-β) likely will be an important area of clinical investigation in the near future. Understanding the various pathways involved in stimulating TGF-β in the diabetic kidney is of paramount importance in devising strategies to combat the development and progression of diabetic nephropathy. In this review we highlight the major pathways involved in stimulating TGF-β production by increased glucose levels and discuss the therapeutic implications thereof.

AB - Summary: The recognition that the drivers of matrix accumulation is an appropriate therapeutic target for diabetic nephropathy is now accepted by the nephrology and pharmaceutical communities. Interventions focused around transforming growth factor-β (TGF-β) likely will be an important area of clinical investigation in the near future. Understanding the various pathways involved in stimulating TGF-β in the diabetic kidney is of paramount importance in devising strategies to combat the development and progression of diabetic nephropathy. In this review we highlight the major pathways involved in stimulating TGF-β production by increased glucose levels and discuss the therapeutic implications thereof.

KW - HETE

KW - Protein kinase C

KW - decorin

KW - glucose excursion

KW - macrophages

KW - podocytes

KW - reactive oxygen species

KW - thrombospondin

KW - upstream stimulatory factor

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Regulation of Transforming Growth Factor β in Diabetic Nephropathy: Implications for Treatment

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