Regulation of intestinal IgA responses

Na Xiong, Shaomin Hu

Producción científica: Review articlerevisión exhaustiva

43 Citas (Scopus)

Resumen

The intestine harbors enormous numbers of commensal bacteria and is under frequent attack from food-borne pathogens and toxins. A properly regulated immune response is critical for homeostatic maintenance of commensals and for protection against infection and toxins in the intestine. Immunoglobulin A (IgA) isotype antibodies function specifically in mucosal sites such as the intestines to help maintain intestinal health by binding to and regulating commensal microbiota, pathogens and toxins. IgA antibodies are produced by intestinal IgA antibody-secreting plasma cells generated in gut-associated lymphoid tissues from naïve B cells in response to stimulations of the intestinal bacteria and components. Research on generation, migration, and maintenance of IgA-secreting cells is important in our effort to understand the biology of IgA responses and to help better design vaccines against intestinal infections.

Idioma originalEnglish (US)
Páginas (desde-hasta)2645-2655
Número de páginas11
PublicaciónCellular and Molecular Life Sciences
Volumen72
N.º14
DOI
EstadoPublished - jul 24 2015
Publicado de forma externa

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Molecular Medicine
  • Molecular Biology
  • Cell Biology
  • Pharmacology

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