Resumen
Although studies of Ames and Snell dwarf mice have suggested possible important roles of the growth hormone (GH)/ insulin-like growth factor-1 (IGF-1) axis in aging and age-related diseases, the results cannot rule out the possibility of other hormonal changes playing an important role in the life extension exhibited by these dwarf mice. Therefore, growth hormone receptor/binding protein (GHR/BP) knockout (KO) mice would be valuable animals to directly assess the roles of somatotropic axis in aging and age-related diseases because the primary hormonal change is due to GH/IGF-1 defi-ciency. Our pathological findings showed GHR/BP KO mice to have a lower incidence and delayed occurrence of fatal neoplastic lesions compared with their wild-type littermates. These changes of fatal neoplasms are similar to the effects observed with calorie restriction and therefore could possibly be a major contributing factor to the extended life span observed in the GHR/BP KO mice.
Idioma original | English (US) |
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Páginas (desde-hasta) | 522-529 |
Número de páginas | 8 |
Publicación | Journals of Gerontology - Series A Biological Sciences and Medical Sciences |
Volumen | 64 |
N.º | 5 |
DOI | |
Estado | Published - may 2009 |
ASJC Scopus subject areas
- General Medicine