Redox-sensitive signaling factors as a novel molecular targets for cancer therapy

J. Daniel Pennington, Tony Jau Cheng Wang, Phuongmai Nguyen, Lunching Sun, Kheem Bisht, Deedee Smart, David Gius

Resultado de la investigación: Articlerevisión exhaustiva

73 Citas (Scopus)

Resumen

Tumor cells undergoing proliferation, de-differentiation and progression depend on a complex set of respiratory pathways to generate the necessary energy. The metabolites from these pathways produce significant oxidative stress and must be buffered to prevent permanent cell damage and cell death. It is now clear that, in order to cope with and defend against the detrimental effects of oxidative stress, a series of redox-sensitive, pro-survival signaling pathways and factors regulate a complex intracellular redox buffering network. This review develops the hypothesis that tumor cells use these redox-sensitive, pro-survival signaling pathways and factors - up-regulated due to increased tumor cell respiration - to evade the damaging and cytotoxic effects of specific anticancer agents. It further suggests that redox-sensitive, signaling factors may be potential novel targets for drug discovery.

Idioma originalEnglish (US)
Páginas (desde-hasta)322-330
Número de páginas9
PublicaciónDrug Resistance Updates
Volumen8
N.º5
DOI
EstadoPublished - oct. 2005
Publicado de forma externa

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Cancer Research
  • Infectious Diseases
  • Pharmacology (medical)

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