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Recording Leukocyte Rolling and Adhesion on Meningeal Vessels by Intravital Microscopy

Producción científica: Chapter

Resumen

Leukocyte infiltration in the central nervous system (CNS) has been implicated in several neuroinflammatory diseases, being an important step in the development of inflammatory response in the brain. The use of intravital microscopy technique allows direct in vivo assessment of leukocyte rolling and adhesion on cortical meningeal vessels. The current review highlights the use of intravital microscopy and its association with neuroinflammatory parameters in different models of experimental brain diseases such as HSV-1 encephalitis, dengue encephalitis, cerebral malaria, and hepatic encephalopathy. Herein, we also describe a detailed protocol of intravital microscopy of meningeal vessels, its advantages and major concerns.

Idioma originalEnglish (US)
Título de la publicación alojadaNeuromethods
EditorialHumana Press
Páginas315-327
Número de páginas13
DOI
EstadoPublished - 2019
Publicado de forma externa

Serie de la publicación

NombreNeuromethods
Volumen142
ISSN (versión impresa)0893-2336
ISSN (versión digital)1940-6045

ASJC Scopus subject areas

  • General Neuroscience
  • General Biochemistry, Genetics and Molecular Biology
  • General Pharmacology, Toxicology and Pharmaceutics
  • Psychiatry and Mental health

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