Recombination-dependent mutation in non-dividing cells

Susan M. Rosenberg; Reuben S. Harris; Simonne Longerich; Anne M. Galloway

doi:10.1016/0027-5107(95)00092-5

Recombination-dependent mutation in non-dividing cells

Susan M. Rosenberg, Reuben S. Harris, Simonne Longerich, Anne M. Galloway

Producción científica: Article › revisión exhaustiva

36 Citas (Scopus)

Resumen

Over the past 6 years an unexpected way of making mutations in bacteria has challenged concepts of the genetic mechanisms behind evolution. Mechanistic studies of these so called 'adaptive' mutations are revealing a novel molecular mechanism involving DNA double-strand breaks, genetic recombination, probable DNA polymerase errors, and the possible suspension of mismatch repair during the reversion of a lac frameshift mutation in Escherichia coli. The molecular details of this process are altering our understanding of how mutations form in non-dividing cells.

Idioma original	English (US)
Páginas (desde-hasta)	69-76
Número de páginas	8
Publicación	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volumen	350
N.º	1
DOI	https://doi.org/10.1016/0027-5107(95)00092-5
Estado	Published - feb 19 1996
Publicado de forma externa	Sí

ASJC Scopus subject areas

Genetics
Molecular Biology
Health, Toxicology and Mutagenesis

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title = "Recombination-dependent mutation in non-dividing cells",

abstract = "Over the past 6 years an unexpected way of making mutations in bacteria has challenged concepts of the genetic mechanisms behind evolution. Mechanistic studies of these so called 'adaptive' mutations are revealing a novel molecular mechanism involving DNA double-strand breaks, genetic recombination, probable DNA polymerase errors, and the possible suspension of mismatch repair during the reversion of a lac frameshift mutation in Escherichia coli. The molecular details of this process are altering our understanding of how mutations form in non-dividing cells.",

keywords = "Adaptive mutation, DNA double-strand break, Directed mutation, Escherichia coli, Mismatch repair, RecA, RecBCD, Recombination, Repent instability",

author = "Rosenberg, \{Susan M.\} and Harris, \{Reuben S.\} and Simonne Longerich and Galloway, \{Anne M.\}",

note = "Funding Information: We thank G. Haljan, P.J. Hastings and H. Razavy for commentso n the manuscript.S upportedb y grants from Natural Sciences and Engineering Research Council of Canada (NSERC), Medical Research Council of Canada. and the Alberta Heritage Foundation for Medical Research (AHFMR). an AHFMR graduate studentship, NSERC graduate studentship, Walter H. Johns graduate studentship and Lionel McLeod fellowship to RSH. and an AHFMR postdoctoral fellowship to AMG. SMR is an Alberta Heritage Medical Scholar.",

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doi = "10.1016/0027-5107(95)00092-5",

language = "English (US)",

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pages = "69--76",

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T1 - Recombination-dependent mutation in non-dividing cells

AU - Rosenberg, Susan M.

AU - Harris, Reuben S.

AU - Longerich, Simonne

AU - Galloway, Anne M.

N1 - Funding Information: We thank G. Haljan, P.J. Hastings and H. Razavy for commentso n the manuscript.S upportedb y grants from Natural Sciences and Engineering Research Council of Canada (NSERC), Medical Research Council of Canada. and the Alberta Heritage Foundation for Medical Research (AHFMR). an AHFMR graduate studentship, NSERC graduate studentship, Walter H. Johns graduate studentship and Lionel McLeod fellowship to RSH. and an AHFMR postdoctoral fellowship to AMG. SMR is an Alberta Heritage Medical Scholar.

PY - 1996/2/19

Y1 - 1996/2/19

N2 - Over the past 6 years an unexpected way of making mutations in bacteria has challenged concepts of the genetic mechanisms behind evolution. Mechanistic studies of these so called 'adaptive' mutations are revealing a novel molecular mechanism involving DNA double-strand breaks, genetic recombination, probable DNA polymerase errors, and the possible suspension of mismatch repair during the reversion of a lac frameshift mutation in Escherichia coli. The molecular details of this process are altering our understanding of how mutations form in non-dividing cells.

AB - Over the past 6 years an unexpected way of making mutations in bacteria has challenged concepts of the genetic mechanisms behind evolution. Mechanistic studies of these so called 'adaptive' mutations are revealing a novel molecular mechanism involving DNA double-strand breaks, genetic recombination, probable DNA polymerase errors, and the possible suspension of mismatch repair during the reversion of a lac frameshift mutation in Escherichia coli. The molecular details of this process are altering our understanding of how mutations form in non-dividing cells.

KW - Adaptive mutation

KW - DNA double-strand break

KW - Directed mutation

KW - Escherichia coli

KW - Mismatch repair

KW - RecA

KW - RecBCD

KW - Recombination

KW - Repent instability

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U2 - 10.1016/0027-5107(95)00092-5

DO - 10.1016/0027-5107(95)00092-5

M3 - Article

C2 - 8657199

AN - SCOPUS:0030070432

SN - 0027-5107

VL - 350

SP - 69

EP - 76

JO - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

JF - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

IS - 1

ER -

Recombination-dependent mutation in non-dividing cells

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