Reactive oxygen species in normal and tumor stem cells

Daohong Zhou, Lijian Shao, Douglas R. Spitz

Resultado de la investigación: Chapter

228 Citas (Scopus)

Resumen

Reactive oxygen species (ROS) play an important role in determining the fate of normal stem cells. Low levels of ROS are required for stem cells to maintain quiescence and self-renewal. Increases in ROS production cause stem cell proliferation/differentiation, senescence, and apoptosis in a dose-dependent manner, leading to their exhaustion. Therefore, the production of ROS in stem cells is tightly regulated to ensure that they have the ability to maintain tissue homeostasis and repair damaged tissues for the life span of an organism. In this chapter, we discuss how the production of ROS in normal stem cells is regulated by various intrinsic and extrinsic factors and how the fate of these cells is altered by the dysregulation of ROS production under various pathological conditions. In addition, the implications of the aberrant production of ROS by tumor stem cells for tumor progression and treatment are also discussed.

Idioma originalEnglish (US)
Título de la publicación alojadaAdvances in Cancer Research
EditorialAcademic Press Inc.
Páginas1-67
Número de páginas67
DOI
EstadoPublished - 2014
Publicado de forma externa

Serie de la publicación

NombreAdvances in Cancer Research
Volumen122
ISSN (versión impresa)0065-230X

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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