RATE OF ACCUMULATION OF ACETYLCHOLINE IN DISCRETE REGIONS OF THE RAT BRAIN AFTER DICHLORVOS TREATMENT

W. B. Stavinoha; A. T. Modak; S. T. Weintraub

doi:10.1111/j.1471-4159.1976.tb02618.x

RATE OF ACCUMULATION OF ACETYLCHOLINE IN DISCRETE REGIONS OF THE RAT BRAIN AFTER DICHLORVOS TREATMENT

W. B. Stavinoha, A. T. Modak, S. T. Weintraub

Department of Biochemistry & Structural Biology

Producción científica: Article › revisión exhaustiva

48 Citas (Scopus)

Resumen

Abstract– The time course for accumulation of acetylcholine was measured in rat brain regions after treatment with 15 mg/kg, i.v., dichlorvos. With this dose of dichlorvos 84‐96% of the brain cholinester‐ase is inhibited within 1 min. After killing and concomitant enzyme inactivation through microwave irradiation, the acetylcholine levels were measured by pyrolysis‐gas chromatography. In the brain regions studied, the striatum had the highest rate of accumulation of acetylcholine and the cerebellum had the lowest. The calculated turnover time in minutes for the regions of the brain were cerebral cortex 0.9; hippocampus 1; striatum 1.4; cerebellum 1.7; medulla‐pons 2.2; midbrain 4.5; thalamus 5.6.

Idioma original	English (US)
Páginas (desde-hasta)	1375-1378
Número de páginas	4
Publicación	Journal of Neurochemistry
Volumen	27
N.º	6
DOI	https://doi.org/10.1111/j.1471-4159.1976.tb02618.x
Estado	Published - dic 1976

ASJC Scopus subject areas

Biochemistry
Cellular and Molecular Neuroscience

Acceder al documento

10.1111/j.1471-4159.1976.tb02618.x

Otros archivos y enlaces

Citar esto

@article{d81b71f489c14aefbb69107d003a05ef,

title = "RATE OF ACCUMULATION OF ACETYLCHOLINE IN DISCRETE REGIONS OF THE RAT BRAIN AFTER DICHLORVOS TREATMENT",

abstract = "Abstract– The time course for accumulation of acetylcholine was measured in rat brain regions after treatment with 15 mg/kg, i.v., dichlorvos. With this dose of dichlorvos 84‐96% of the brain cholinester‐ase is inhibited within 1 min. After killing and concomitant enzyme inactivation through microwave irradiation, the acetylcholine levels were measured by pyrolysis‐gas chromatography. In the brain regions studied, the striatum had the highest rate of accumulation of acetylcholine and the cerebellum had the lowest. The calculated turnover time in minutes for the regions of the brain were cerebral cortex 0.9; hippocampus 1; striatum 1.4; cerebellum 1.7; medulla‐pons 2.2; midbrain 4.5; thalamus 5.6.",

author = "Stavinoha, {W. B.} and Modak, {A. T.} and Weintraub, {S. T.}",

year = "1976",

month = dec,

doi = "10.1111/j.1471-4159.1976.tb02618.x",

language = "English (US)",

volume = "27",

pages = "1375--1378",

journal = "Journal of Neurochemistry",

issn = "0022-3042",

publisher = "Wiley-Blackwell",

number = "6",

}

TY - JOUR

T1 - RATE OF ACCUMULATION OF ACETYLCHOLINE IN DISCRETE REGIONS OF THE RAT BRAIN AFTER DICHLORVOS TREATMENT

AU - Stavinoha, W. B.

AU - Modak, A. T.

AU - Weintraub, S. T.

PY - 1976/12

Y1 - 1976/12

N2 - Abstract– The time course for accumulation of acetylcholine was measured in rat brain regions after treatment with 15 mg/kg, i.v., dichlorvos. With this dose of dichlorvos 84‐96% of the brain cholinester‐ase is inhibited within 1 min. After killing and concomitant enzyme inactivation through microwave irradiation, the acetylcholine levels were measured by pyrolysis‐gas chromatography. In the brain regions studied, the striatum had the highest rate of accumulation of acetylcholine and the cerebellum had the lowest. The calculated turnover time in minutes for the regions of the brain were cerebral cortex 0.9; hippocampus 1; striatum 1.4; cerebellum 1.7; medulla‐pons 2.2; midbrain 4.5; thalamus 5.6.

AB - Abstract– The time course for accumulation of acetylcholine was measured in rat brain regions after treatment with 15 mg/kg, i.v., dichlorvos. With this dose of dichlorvos 84‐96% of the brain cholinester‐ase is inhibited within 1 min. After killing and concomitant enzyme inactivation through microwave irradiation, the acetylcholine levels were measured by pyrolysis‐gas chromatography. In the brain regions studied, the striatum had the highest rate of accumulation of acetylcholine and the cerebellum had the lowest. The calculated turnover time in minutes for the regions of the brain were cerebral cortex 0.9; hippocampus 1; striatum 1.4; cerebellum 1.7; medulla‐pons 2.2; midbrain 4.5; thalamus 5.6.

UR - http://www.scopus.com/inward/record.url?scp=0017091056&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017091056&partnerID=8YFLogxK

U2 - 10.1111/j.1471-4159.1976.tb02618.x

DO - 10.1111/j.1471-4159.1976.tb02618.x

M3 - Article

C2 - 1003212

AN - SCOPUS:0017091056

SN - 0022-3042

VL - 27

SP - 1375

EP - 1378

JO - Journal of Neurochemistry

JF - Journal of Neurochemistry

IS - 6

ER -

RATE OF ACCUMULATION OF ACETYLCHOLINE IN DISCRETE REGIONS OF THE RAT BRAIN AFTER DICHLORVOS TREATMENT

Resumen

ASJC Scopus subject areas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto