@article{f70fe6b76d42436f9d0bdd573028015b,
title = "Rasagiline for amyotrophic lateral sclerosis: A randomized, controlled trial",
abstract = "Introduction: Rasagiline is a monoamine oxidase B (MAO-B) inhibitor with possible neuroprotective effects in patients with amyotrophic lateral sclerosis (ALS). Methods: We performed a randomized, double-blind, placebo-controlled trial of 80 ALS participants with enrichment of the placebo group with historical controls (n = 177) at 10 centers in the United States. Participants were randomized in a 3:1 ratio to 2 mg/day rasagiline or placebo. The primary outcome was average slope of decline on the ALS Functional Rating Scale—Revised (ALSFRS-R). Secondary measures included slow vital capacity, survival, mitochondrial and molecular biomarkers, and adverse-event reporting. Results: There was no difference in the average 12-month ALSFRS-R slope between rasagiline and the mixed placebo and historical control cohorts. Rasagiline did not show signs of drug-target engagement in urine and blood biomarkers. Rasagiline was well tolerated with no serious adverse events. Discussion: Rasagiline did not alter disease progression compared with controls over 12 months of treatment. Muscle Nerve 59:201–207, 2019.",
keywords = "MAO-B inhibitor, amyotrophic lateral sclerosis, biomarker, controlled clinical trial, motor neuron disease, randomized, rasagiline",
author = "{The Rasagiline Investigators of the Muscle Study Group and Western ALS Consortium} and Statland, {Jeffrey M.} and Dan Moore and Yunxia Wang and Maureen Walsh and Tahseen Mozaffar and Lauren Elman and Nations, {Sharon P.} and Hiroshi Mitsumoto and Fernandes, {J. Americo} and David Saperstein and Ghazala Hayat and Laura Herbelin and Chafic Karam and Jonathan Katz and Wilkins, {Heather M.} and Abdulbaki Agbas and Swerdlow, {Russell H.} and Santella, {Regina M.} and Dimachkie, {Mazen M.} and Barohn, {Richard J.} and Russell Swerdlow and Yunxia Wang and Jeffrey Statland and Dimachkie, {Mazen M.} and Melanie Glenn and Mamatha Pasnoor and Maureen Walsh and Kelley Emmons and Kathryn Johns and Yolanda Harness and Laura Herbelin and Jonathan Katz and Miller, {Robert G.} and Dallas Forshew and Marguerite Engel and Tahseen Mozaffar and Namita Goyal and Tiyonnoh Cash and Veena Mathew and Veronica Martin and David Saperstein and Todd Levine and Lynn Flynne and Chafic Karam and Diana Dimtrov and Lauren Elman and Leo McCluskey and Kelly Almasy and Mary Kelley and Carlayne Jackson",
note = "Publisher Copyright: {\textcopyright} 2018 Wiley Periodicals, Inc.",
year = "2019",
month = feb,
doi = "10.1002/mus.26335",
language = "English (US)",
volume = "59",
pages = "201--207",
journal = "Muscle and Nerve",
issn = "0148-639X",
publisher = "John Wiley & Sons Inc.",
number = "2",
}