Randomized double-blind study of botulinum toxin type B for sialorrhea in ALS patients

Carlayne E. Jackson; Gary Gronseth; Jeffrey Rosenfeld; Richard J. Barohn; Richard Dubinsky; C. Blake Simpson; April Mcvey; Pamela P. Kittrell; Ruth King; Laura Herbelin; Robert Griggs; Rabi Tawil; Carlayne Jackson; John T. Kissel; Shree Pandya; Karen Downing; Michael Rose; Michael McDermott

doi:10.1002/mus.21213

Randomized double-blind study of botulinum toxin type B for sialorrhea in ALS patients

Carlayne E. Jackson, Gary Gronseth, Jeffrey Rosenfeld, Richard J. Barohn, Richard Dubinsky, C. Blake Simpson, April Mcvey, Pamela P. Kittrell, Ruth King, Laura Herbelin, Robert Griggs, Rabi Tawil, Carlayne Jackson, John T. Kissel, Shree Pandya, Karen Downing, Michael Rose, Michael McDermott

Producción científica: Article › revisión exhaustiva

128 Citas (Scopus)

Resumen

Twenty ALS patients with sialorrhea refractory to medical therapy were enrolled in this double-blind, randomized study to receive either 2,500 U of botulinum toxin type B (BTxb) or placebo into the bilateral parotid and submandibular glands using electromyographic guidance. Patients who received BTxb reported a global impression of improvement of 82% at 2 weeks compared to 38% of those who received placebo (P < 0.05). This significant effect was sustained at 4 weeks. At 12 weeks, 50% of patients who received BTxb continued to report improvement compared to 14% of those who received placebo. There were no significant adverse events, including dysphagia, in the BTxb group, and there was no significant increase in the rate of decline of vital capacity.

Idioma original	English (US)
Páginas (desde-hasta)	137-143
Número de páginas	7
Publicación	Muscle and Nerve
Volumen	39
N.º	2
DOI	https://doi.org/10.1002/mus.21213
Estado	Published - feb 2009

ASJC Scopus subject areas

Physiology
Clinical Neurology
Cellular and Molecular Neuroscience
Physiology (medical)

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10.1002/mus.21213

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Jackson, C. E., Gronseth, G., Rosenfeld, J., Barohn, R. J., Dubinsky, R., Simpson, C. B., Mcvey, A., Kittrell, P. P., King, R., Herbelin, L., Griggs, R., Tawil, R., Jackson, C., Kissel, J. T., Pandya, S., Downing, K., Rose, M., & McDermott, M. (2009). Randomized double-blind study of botulinum toxin type B for sialorrhea in ALS patients. Muscle and Nerve, 39(2), 137-143. https://doi.org/10.1002/mus.21213

Jackson, CE, Gronseth, G, Rosenfeld, J, Barohn, RJ, Dubinsky, R, Simpson, CB, Mcvey, A, Kittrell, PP, King, R, Herbelin, L, Griggs, R, Tawil, R, Jackson, C, Kissel, JT, Pandya, S, Downing, K, Rose, M & McDermott, M 2009, 'Randomized double-blind study of botulinum toxin type B for sialorrhea in ALS patients', Muscle and Nerve, vol. 39, n.º 2, pp. 137-143. https://doi.org/10.1002/mus.21213

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title = "Randomized double-blind study of botulinum toxin type B for sialorrhea in ALS patients",

abstract = "Twenty ALS patients with sialorrhea refractory to medical therapy were enrolled in this double-blind, randomized study to receive either 2,500 U of botulinum toxin type B (BTxb) or placebo into the bilateral parotid and submandibular glands using electromyographic guidance. Patients who received BTxb reported a global impression of improvement of 82\% at 2 weeks compared to 38\% of those who received placebo (P < 0.05). This significant effect was sustained at 4 weeks. At 12 weeks, 50\% of patients who received BTxb continued to report improvement compared to 14\% of those who received placebo. There were no significant adverse events, including dysphagia, in the BTxb group, and there was no significant increase in the rate of decline of vital capacity.",

keywords = "Amyotrophic lateral sclerosis, Botulinum toxin, Drooling, Quality of life, Sialorrhea",

author = "Jackson, \{Carlayne E.\} and Gary Gronseth and Jeffrey Rosenfeld and Barohn, \{Richard J.\} and Richard Dubinsky and Simpson, \{C. Blake\} and April Mcvey and Kittrell, \{Pamela P.\} and Ruth King and Laura Herbelin and Robert Griggs and Rabi Tawil and Carlayne Jackson and Kissel, \{John T.\} and Shree Pandya and Karen Downing and Michael Rose and Michael McDermott",

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doi = "10.1002/mus.21213",

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AU - Jackson, Carlayne E.

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AU - Rosenfeld, Jeffrey

AU - Barohn, Richard J.

AU - Dubinsky, Richard

AU - Simpson, C. Blake

AU - Mcvey, April

AU - Kittrell, Pamela P.

AU - King, Ruth

AU - Herbelin, Laura

AU - Griggs, Robert

AU - Tawil, Rabi

AU - Jackson, Carlayne

AU - Kissel, John T.

AU - Pandya, Shree

AU - Downing, Karen

AU - Rose, Michael

AU - McDermott, Michael

PY - 2009/2

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N2 - Twenty ALS patients with sialorrhea refractory to medical therapy were enrolled in this double-blind, randomized study to receive either 2,500 U of botulinum toxin type B (BTxb) or placebo into the bilateral parotid and submandibular glands using electromyographic guidance. Patients who received BTxb reported a global impression of improvement of 82% at 2 weeks compared to 38% of those who received placebo (P < 0.05). This significant effect was sustained at 4 weeks. At 12 weeks, 50% of patients who received BTxb continued to report improvement compared to 14% of those who received placebo. There were no significant adverse events, including dysphagia, in the BTxb group, and there was no significant increase in the rate of decline of vital capacity.

AB - Twenty ALS patients with sialorrhea refractory to medical therapy were enrolled in this double-blind, randomized study to receive either 2,500 U of botulinum toxin type B (BTxb) or placebo into the bilateral parotid and submandibular glands using electromyographic guidance. Patients who received BTxb reported a global impression of improvement of 82% at 2 weeks compared to 38% of those who received placebo (P < 0.05). This significant effect was sustained at 4 weeks. At 12 weeks, 50% of patients who received BTxb continued to report improvement compared to 14% of those who received placebo. There were no significant adverse events, including dysphagia, in the BTxb group, and there was no significant increase in the rate of decline of vital capacity.

KW - Amyotrophic lateral sclerosis

KW - Botulinum toxin

KW - Drooling

KW - Quality of life

KW - Sialorrhea

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Randomized double-blind study of botulinum toxin type B for sialorrhea in ALS patients

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