TY - JOUR
T1 - Quantitative analysis of hydralazine pyruvic acid hydrazone, the major plasma metabolite of hydralazine
AU - Haegele, Klaus D.
AU - Skrdlant, Harold B.
AU - Talseth, Tore
AU - McNay, John L.
AU - Shepherd, Alexander M.M.
AU - Clementi, William A.
N1 - Funding Information:
This work was supportedb y NIH/NXGM!S grant No. GM 24092, the Veterans Admin.&&on, NIH/NIGMS grant No. GM 07014 and an American Heart Association, Texas AfEliate grant. Tore Taketh is a recipient of a Merck, Sharp & Dohme LntemationalF eUowsEipi n Clinical Phatmacol ogy. T&e techniczLals sk3ta.n~ ofM rs. Susan B. Ktiaad Ms. Kay BaU&er, as welt as the semeta&I heIp ofI !&. BarbaraB oyle and Ms. Diana Resemiezi s most grat&Wy appreciated.
PY - 1980/1/4
Y1 - 1980/1/4
N2 - A specific, high-performance liquid chromatographic techinique for the measurement of hydralazine pyruvic acid hydrazone is described. This method utilized reversed-phase chromatography for the separation of this hydrophilic metabolite of hydralazine from other fluid constituents present in serum, plasma, or urine of human volunteers and rabbits receiving hydralazine. Detection of the compound of interest is accomplished spectrophotometrically at 250 nm.
AB - A specific, high-performance liquid chromatographic techinique for the measurement of hydralazine pyruvic acid hydrazone is described. This method utilized reversed-phase chromatography for the separation of this hydrophilic metabolite of hydralazine from other fluid constituents present in serum, plasma, or urine of human volunteers and rabbits receiving hydralazine. Detection of the compound of interest is accomplished spectrophotometrically at 250 nm.
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U2 - 10.1016/S0021-9673(00)87883-8
DO - 10.1016/S0021-9673(00)87883-8
M3 - Article
C2 - 7358814
AN - SCOPUS:0018865165
SN - 0021-9673
VL - 187
SP - 171
EP - 179
JO - Journal of Chromatography A
JF - Journal of Chromatography A
IS - 1
ER -