Quantitative analysis of hydralazine pyruvic acid hydrazone, the major plasma metabolite of hydralazine

Klaus D. Haegele, Harold B. Skrdlant, Tore Talseth, John L. McNay, Alexander M.M. Shepherd, William A. Clementi

Producción científica: Articlerevisión exhaustiva

17 Citas (Scopus)

Resumen

A specific, high-performance liquid chromatographic techinique for the measurement of hydralazine pyruvic acid hydrazone is described. This method utilized reversed-phase chromatography for the separation of this hydrophilic metabolite of hydralazine from other fluid constituents present in serum, plasma, or urine of human volunteers and rabbits receiving hydralazine. Detection of the compound of interest is accomplished spectrophotometrically at 250 nm.

Idioma originalEnglish (US)
Páginas (desde-hasta)171-179
Número de páginas9
PublicaciónJournal of Chromatography A
Volumen187
N.º1
DOI
EstadoPublished - ene 4 1980

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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