Pyoverdine, a siderophore from Pseudomonas aeruginosa, translocates into C. elegans, removes iron, and activates a distinct host response

Donghoon Kang, Daniel R. Kirienkoa, Phillip Webster, Alfred L. Fisher, Natalia V. Kirienko

    Resultado de la investigación: Articlerevisión exhaustiva

    69 Citas (Scopus)

    Resumen

    Pseudomonas aeruginosa, a re-emerging, opportunistic human pathogen, encodes a variety of virulence determinants. Pyoverdine, a siderophore produced by this bacterium, is essential for pathogenesis in mammalian infections. This observation is generally attributed to its roles in acquiring iron and/or regulating other virulence factors. Here we report that pyoverdine translocates into the host, where it binds and extracts iron. Pyoverdine-mediated iron extraction damages host mitochondria, disrupting their function and triggering mitochondrial turnover via autophagy. The host detects this damage via a conserved mitochondrial surveillance pathway mediated by the ESRE network. Our findings illuminate the pathogenic mechanisms of pyoverdine and highlight the importance of this bacterial product in host-pathogen interactions.

    Idioma originalEnglish (US)
    Páginas (desde-hasta)804-817
    Número de páginas14
    PublicaciónVirulence
    Volumen9
    N.º1
    DOI
    EstadoPublished - ene. 1 2018

    ASJC Scopus subject areas

    • Parasitology
    • Microbiology
    • Immunology
    • Microbiology (medical)
    • Infectious Diseases

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