TY - CHAP
T1 - Pulp Injury and Changing Trends in Treatment
AU - Hargreaves, Kenneth M.
AU - Diogenes, Anibal
AU - Teixeira, Fabricio B.
N1 - Funding Information:
The authors deny conflicts of interest. Supported in part by R34 DE20864 and by NCATS UL1TR000149. This review was adapted from a prior review published in the Journal of Endodontics 2013;39:S30-43.
Publisher Copyright:
© 2015 Elsevier Inc. All rights reserved.
PY - 2015
Y1 - 2015
N2 - In contrast to the high long-term survival rates (>. 93%) of conventional endodontic treatment applied to mature permanent teeth, the treatment of the immature permanent tooth with a necrotic root canal system and apical periodontitis is challenging, due in part to incomplete root development leading to thin dentinal walls and reduced overall length. Conventional apexification procedures treat apical periodontitis in immature teeth, but the cases often have a poor prognosis due to weak root structures. Recent studies have employed a tissue engineering approach designed to regenerate a pulp-like tissue, resulting in continued radiographic root development, healing of apical periodontitis, and improved overall tooth survival. This chapter reviews the biological basis of regenerative endodontics and provides a perspective to interpret ongoing research in this dynamic area.
AB - In contrast to the high long-term survival rates (>. 93%) of conventional endodontic treatment applied to mature permanent teeth, the treatment of the immature permanent tooth with a necrotic root canal system and apical periodontitis is challenging, due in part to incomplete root development leading to thin dentinal walls and reduced overall length. Conventional apexification procedures treat apical periodontitis in immature teeth, but the cases often have a poor prognosis due to weak root structures. Recent studies have employed a tissue engineering approach designed to regenerate a pulp-like tissue, resulting in continued radiographic root development, healing of apical periodontitis, and improved overall tooth survival. This chapter reviews the biological basis of regenerative endodontics and provides a perspective to interpret ongoing research in this dynamic area.
KW - Pulpal revascularization
KW - Regenerative endodontics
KW - Stem cells
KW - Tissue engineering
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U2 - 10.1016/B978-0-12-397157-9.00035-7
DO - 10.1016/B978-0-12-397157-9.00035-7
M3 - Chapter
AN - SCOPUS:84942741703
SN - 9780123971579
SP - 397
EP - 404
BT - Stem Cell Biology and Tissue Engineering in Dental Sciences
PB - Elsevier Inc.
ER -