Psychological trauma and the genetic overlap between posttraumatic stress disorder and major depressive disorder

The Million Veteran Program, Post Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium

Producción científica: Articlerevisión exhaustiva

14 Citas (Scopus)

Resumen

Background. Posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) are commonly reported co-occurring mental health consequences of psychological trauma exposure. The disorders have high genetic overlap. Trauma is a complex phenotype but research suggests that trauma sensitivity has a heritable basis. We investigated whether sensitivity to trauma in those with MDD reflects a similar genetic component in those with PTSD. Methods. Genetic correlations between PTSD and MDD in individuals reporting trauma and MDD in individuals not reporting trauma were estimated, as well as with recurrent MDD and single-episode MDD, using genome-wide association study (GWAS) summary statistics. Genetic correlations were replicated using PTSD data from the Psychiatric Genomics Consortium and the Million Veteran Program. Polygenic risk scores were generated in UK Biobank participants who met the criteria for lifetime MDD (N = 29 471). We investigated whether genetic loading for PTSD was associated with reporting trauma in these individuals. Results. Genetic loading for PTSD was significantly associated with reporting trauma in individuals with MDD [OR 1.04 (95% CI 1.01-1.07), Empirical-p = 0.02]. PTSD was significantly more genetically correlated with recurrent MDD than with MDD in individuals not reporting trauma (rg differences = ~0.2, p < 0.008). Participants who had experienced recurrent MDD reported significantly higher rates of trauma than participants who had experienced singleepisode MDD (X2 > 166, p < 0.001) Conclusions. Our findings point towards the existence of genetic variants associated with trauma sensitivity that might be shared between PTSD and MDD, although replication with better powered GWAS is needed. Our findings corroborate previous research highlighting trauma exposure as a key risk factor for recurrent MDD.

Idioma originalEnglish (US)
Páginas (desde-hasta)3975-3984
Número de páginas10
PublicaciónPsychological Medicine
Volumen52
N.º16
DOI
EstadoPublished - dic 4 2022
Publicado de forma externa

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health

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