Protection of dopaminergic neurons by electroconvulsive shock in an animal model of Parkinson's disease

Agustín Anastasia, Gabriel A. De Erausquin, José Wojnacki, Daniel H. Mascó

Producción científica: Articlerevisión exhaustiva

18 Citas (Scopus)

Resumen

Electroconvulsive shock (ECS) improves motor function in Parkinson's disease. In rats, ECS stimulates the expression of various factors some of which have been proposed to exert neuroprotective actions. We have investigated the effects of ECS on 6-hydroxydopamine (6-OHDA)-injected rats. Three weeks after a unilateral administration of 6-OHDA, 85-95% nigral dopaminergic neurons are lost. Chronic ECS prevented this cell loss, protect the nigrostriatal pathway (assessed by FloroGold retrograde labeling) and reduce motor impairment in 6-OHDA-treated animals. Injection of 6-OHDA caused loss of expression of glial cell-line derived neurotrophic factor (GDNF) in the substantia nigra. Chronic ECS completely prevented this loss of GDNF expression in 6-OHDA-treated animals. We also found that protected dopaminergic neurons co-express GDNF receptor proteins. These results strongly suggest that endogenous changes in GDNF expression may participate in the neuroprotective mechanism of ECS against 6-OHDA induced toxicity.

Idioma originalEnglish (US)
Páginas (desde-hasta)1542-1552
Número de páginas11
PublicaciónJournal of neurochemistry
Volumen103
N.º4
DOI
EstadoPublished - nov 2007
Publicado de forma externa

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Biochemistry

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