Promoters of human cosmc and T-synthase genes are similar in structure, yet different in epigenetic regulation

Junwei Zeng; Rongjuan Mi; Yingchun Wang; Yujing Li; Li Lin; Bing Yao; Lina Song; Irma Van Die; Arlene B. Chapman; Richard D. Cummings; Peng Jin; Tongzhong Ju

doi:10.1074/jbc.M115.654244

Promoters of human cosmc and T-synthase genes are similar in structure, yet different in epigenetic regulation

Junwei Zeng, Rongjuan Mi, Yingchun Wang, Yujing Li, Li Lin, Bing Yao, Lina Song, Irma Van Die, Arlene B. Chapman, Richard D. Cummings, Peng Jin, Tongzhong Ju

Producción científica: Article › revisión exhaustiva

19 Citas (Scopus)

Resumen

Background: Transcriptional regulation of human T-synthase and Cosmc is unknown. Results: Minimal promoters for Cosmc and T-synthase are located in CpG islands, and the promoter of Cosmc, but not T-synthase, was hypermethylated in Tn4 B cells. Conclusion: Promoters of Cosmc and T-synthase are similarly structured, yet different in epigenetic regulation. Significance: These data aid in understanding the role of these genes in biology and diseases.

Idioma original	English (US)
Páginas (desde-hasta)	19018-19033
Número de páginas	16
Publicación	Journal of Biological Chemistry
Volumen	290
N.º	31
DOI	https://doi.org/10.1074/jbc.M115.654244
Estado	Published - jul 31 2015
Publicado de forma externa	Sí

ASJC Scopus subject areas

Molecular Biology
Biochemistry
Cell Biology

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title = "Promoters of human cosmc and T-synthase genes are similar in structure, yet different in epigenetic regulation",

abstract = "Background: Transcriptional regulation of human T-synthase and Cosmc is unknown. Results: Minimal promoters for Cosmc and T-synthase are located in CpG islands, and the promoter of Cosmc, but not T-synthase, was hypermethylated in Tn4 B cells. Conclusion: Promoters of Cosmc and T-synthase are similarly structured, yet different in epigenetic regulation. Significance: These data aid in understanding the role of these genes in biology and diseases.",

author = "Junwei Zeng and Rongjuan Mi and Yingchun Wang and Yujing Li and Li Lin and Bing Yao and Lina Song and {Van Die}, Irma and Chapman, {Arlene B.} and Cummings, {Richard D.} and Peng Jin and Tongzhong Ju",

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T1 - Promoters of human cosmc and T-synthase genes are similar in structure, yet different in epigenetic regulation

AU - Zeng, Junwei

AU - Mi, Rongjuan

AU - Wang, Yingchun

AU - Li, Yujing

AU - Lin, Li

AU - Yao, Bing

AU - Song, Lina

AU - Van Die, Irma

AU - Chapman, Arlene B.

AU - Cummings, Richard D.

AU - Jin, Peng

AU - Ju, Tongzhong

PY - 2015/7/31

Y1 - 2015/7/31

N2 - Background: Transcriptional regulation of human T-synthase and Cosmc is unknown. Results: Minimal promoters for Cosmc and T-synthase are located in CpG islands, and the promoter of Cosmc, but not T-synthase, was hypermethylated in Tn4 B cells. Conclusion: Promoters of Cosmc and T-synthase are similarly structured, yet different in epigenetic regulation. Significance: These data aid in understanding the role of these genes in biology and diseases.

AB - Background: Transcriptional regulation of human T-synthase and Cosmc is unknown. Results: Minimal promoters for Cosmc and T-synthase are located in CpG islands, and the promoter of Cosmc, but not T-synthase, was hypermethylated in Tn4 B cells. Conclusion: Promoters of Cosmc and T-synthase are similarly structured, yet different in epigenetic regulation. Significance: These data aid in understanding the role of these genes in biology and diseases.

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Promoters of human cosmc and T-synthase genes are similar in structure, yet different in epigenetic regulation

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