Proinflammatory Cytokine Effects on Mesenchymal Stem Cell Therapy for the Ischemic Heart

Aaron M. Abarbanell; Arthur C. Coffey; John W. Fehrenbacher; Daniel J. Beckman; Jeremy L. Herrmann; Brent Weil; Daniel R. Meldrum

doi:10.1016/j.athoracsur.2009.02.093

Proinflammatory Cytokine Effects on Mesenchymal Stem Cell Therapy for the Ischemic Heart

Aaron M. Abarbanell, Arthur C. Coffey, John W. Fehrenbacher, Daniel J. Beckman, Jeremy L. Herrmann, Brent Weil, Daniel R. Meldrum

Resultado de la investigación: Review article › revisión exhaustiva

Resumen

Mesenchymal stem cells (MSCs) hold great promise for improving myocardial recovery after ischemia. The cardiothoracic surgeon is uniquely positioned to be at the forefront of any clinical application of this therapy. As such, a basic understanding of stem cells and the cytokines that affect stem cell function will be an essential component of the surgeon's ever-expanding knowledge base. This review provides: (1) a general overview of stem cells and MSCs in particular, (2) critically analyzes several cytokines known to alter MSC function, and (3) discusses methods to manipulate cytokine-activated MSCs to improve MSC function for potential clinical application.

Idioma original	English (US)
Páginas (desde-hasta)	1036-1043
Número de páginas	8
Publicación	Annals of Thoracic Surgery
Volumen	88
N.º	3
DOI	https://doi.org/10.1016/j.athoracsur.2009.02.093
Estado	Published - sept 2009
Publicado de forma externa	Sí

ASJC Scopus subject areas

Surgery
Pulmonary and Respiratory Medicine
Cardiology and Cardiovascular Medicine

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10.1016/j.athoracsur.2009.02.093

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title = "Proinflammatory Cytokine Effects on Mesenchymal Stem Cell Therapy for the Ischemic Heart",

abstract = "Mesenchymal stem cells (MSCs) hold great promise for improving myocardial recovery after ischemia. The cardiothoracic surgeon is uniquely positioned to be at the forefront of any clinical application of this therapy. As such, a basic understanding of stem cells and the cytokines that affect stem cell function will be an essential component of the surgeon's ever-expanding knowledge base. This review provides: (1) a general overview of stem cells and MSCs in particular, (2) critically analyzes several cytokines known to alter MSC function, and (3) discusses methods to manipulate cytokine-activated MSCs to improve MSC function for potential clinical application.",

author = "Abarbanell, {Aaron M.} and Coffey, {Arthur C.} and Fehrenbacher, {John W.} and Beckman, {Daniel J.} and Herrmann, {Jeremy L.} and Brent Weil and Meldrum, {Daniel R.}",

note = "Funding Information: This work was supported in part by the United States National Institutes of Health (NIH) R01GM070628, NIH R01HL085595, NIH K99/R00 HL0876077, NIH 1F32HL092718, NIH 1F32HL092719, American Heart Association Grant-in-Aid, and the American Heart Association Post-Doctoral Fellowship 0725663Z.",

year = "2009",

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doi = "10.1016/j.athoracsur.2009.02.093",

language = "English (US)",

volume = "88",

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AU - Abarbanell, Aaron M.

AU - Coffey, Arthur C.

AU - Fehrenbacher, John W.

AU - Beckman, Daniel J.

AU - Herrmann, Jeremy L.

AU - Weil, Brent

AU - Meldrum, Daniel R.

N1 - Funding Information: This work was supported in part by the United States National Institutes of Health (NIH) R01GM070628, NIH R01HL085595, NIH K99/R00 HL0876077, NIH 1F32HL092718, NIH 1F32HL092719, American Heart Association Grant-in-Aid, and the American Heart Association Post-Doctoral Fellowship 0725663Z.

PY - 2009/9

Y1 - 2009/9

N2 - Mesenchymal stem cells (MSCs) hold great promise for improving myocardial recovery after ischemia. The cardiothoracic surgeon is uniquely positioned to be at the forefront of any clinical application of this therapy. As such, a basic understanding of stem cells and the cytokines that affect stem cell function will be an essential component of the surgeon's ever-expanding knowledge base. This review provides: (1) a general overview of stem cells and MSCs in particular, (2) critically analyzes several cytokines known to alter MSC function, and (3) discusses methods to manipulate cytokine-activated MSCs to improve MSC function for potential clinical application.

AB - Mesenchymal stem cells (MSCs) hold great promise for improving myocardial recovery after ischemia. The cardiothoracic surgeon is uniquely positioned to be at the forefront of any clinical application of this therapy. As such, a basic understanding of stem cells and the cytokines that affect stem cell function will be an essential component of the surgeon's ever-expanding knowledge base. This review provides: (1) a general overview of stem cells and MSCs in particular, (2) critically analyzes several cytokines known to alter MSC function, and (3) discusses methods to manipulate cytokine-activated MSCs to improve MSC function for potential clinical application.

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Proinflammatory Cytokine Effects on Mesenchymal Stem Cell Therapy for the Ischemic Heart

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