Proinflammatory Cytokine Effects on Mesenchymal Stem Cell Therapy for the Ischemic Heart

Aaron M. Abarbanell, Arthur C. Coffey, John W. Fehrenbacher, Daniel J. Beckman, Jeremy L. Herrmann, Brent Weil, Daniel R. Meldrum

Resultado de la investigación: Review articlerevisión exhaustiva


Mesenchymal stem cells (MSCs) hold great promise for improving myocardial recovery after ischemia. The cardiothoracic surgeon is uniquely positioned to be at the forefront of any clinical application of this therapy. As such, a basic understanding of stem cells and the cytokines that affect stem cell function will be an essential component of the surgeon's ever-expanding knowledge base. This review provides: (1) a general overview of stem cells and MSCs in particular, (2) critically analyzes several cytokines known to alter MSC function, and (3) discusses methods to manipulate cytokine-activated MSCs to improve MSC function for potential clinical application.

Idioma originalEnglish (US)
Páginas (desde-hasta)1036-1043
Número de páginas8
PublicaciónAnnals of Thoracic Surgery
EstadoPublished - sept 2009
Publicado de forma externa

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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