Profiling DNA methylomes from microarray to genome-scale sequencing

Yi Wen Huang, Tim H.M. Huang, Li Shu Wang

Producción científica: Review articlerevisión exhaustiva

59 Citas (Scopus)

Resumen

DNA cytosine methylation is a central epigenetic modi.cation which plays critical roles in cellular processes including genome regulation, development and disease. Here, we review current and emerging microarray and next-generation sequencing based technologies that enhance our knowledge of DNA methylation pro.ling. Each methodology has limitations and their unique applications, and combinations of several modalities may help build the entire methylome. With advances on next-generation sequencing technologies, it is now possible to globally map the DNA cytosine methylation at single-base resolution, providing new insights into the regulation and dynamics of DNA methylation in genomes.

Idioma originalEnglish (US)
Páginas (desde-hasta)139-147
Número de páginas9
PublicaciónTechnology in Cancer Research and Treatment
Volumen9
N.º2
DOI
EstadoPublished - abr 2010
Publicado de forma externa

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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