Primary murine Chlamydia trachomatis pneumonia in B-cell-deficient mice

D. M. Williams, B. Grubbs, J. Schachter

Resultado de la investigación: Articlerevisión exhaustiva

15 Citas (Scopus)


Mice were rendered deficient in B-cell activity by treatment with anti-μ antibody from birth. These animals were then infected intranasally with murine Chlamydia trachomatis (murine pneumonitis agent [MoPn]). They produced neither local nor systemic antibody to MoPn but had intact delayed-type hypersensitivity to MoPn. Anti-μ-treated mice were not significantly more susceptible to primary invasive infection with MoPn than were control mice, and unrestricted multiplication with MoPn did not occur. The dominant immune response controlling this type of infection is not likely to be antibody.

Idioma originalEnglish (US)
Páginas (desde-hasta)2387-2390
Número de páginas4
PublicaciónInfection and immunity
EstadoPublished - 1987
Publicado de forma externa

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases


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