Primary immunodeficiencies: Genetic risk factors for lymphoma

A. H. Filipovich, A. Mathur, D. Kamat, R. S. Shapiro

Resultado de la investigación: Articlerevisión exhaustiva

203 Citas (Scopus)

Resumen

It has been estimated that up to 25% of patients with certain genetically determined immunodeficiencies will develop tumors, primarily B-cell lymphomas, during their lifetime. Epstein-Barr virus appears to be an important cofactor in the development of lymphoproliferative disorders in patients with primary immunodeficiencies, as well as acquired immunodeficiencies. Additionally, host defects in immunoregulation and/or gene rearrangement, which are features of certain primary immunodeficiencies, probably contribute to the risk of lymphomagenesis in patients at risk.

Idioma originalEnglish (US)
Páginas (desde-hasta)5465s-5467s
PublicaciónCancer Research
Volumen52
N.º19 SUPPL.
EstadoPublished - ene. 1 1992
Publicado de forma externa

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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