Preferential retention of paternal alleles in human retinoblastoma: evidence for genomic imprinting.

R. J. Leach, A. N. Magewu, J. D. Buckley, W. F. Benedict, C. Rother, A. L. Murphree, S. Griegel, M. F. Rajewsky, P. A. Jones

Resultado de la investigación: Articlerevisión exhaustiva

28 Citas (Scopus)

Resumen

The origins of the initial mutations in sporadic retinoblastoma were explored using polymorphic markers from chromosome 13q. The paternal chromosome was maintained in 3 of 3 informative bilateral tumors which had undergone reduction to homozygosity for regions of this chromosome. The paternal chromosome was maintained in 7 of 8 informative unilateral tumors which likewise demonstrated a reduction of homozygosity. These data are in contrast to previously published studies of chromosome retention in unilateral retinoblastoma [Dryja, T. P., Mukai, S., Petersen, R., Rapaport, J. M., Walton, D., and Yandel, D. W. Nature (Lond.), 339: 556-558, 1989; Zhu, Z., Dunn, J. M., Phillips, R. A., Goddard, A. D., Paton, K. E., Becker, A., and Gallie, B. L. Nature (Lond.), 340: 312-313, 1989] and provide the first evidence that genomic imprinting may play a role in this disease.

Idioma originalEnglish (US)
Páginas (desde-hasta)401-406
Número de páginas6
PublicaciónCell growth & differentiation : the molecular biology journal of the American Association for Cancer Research
Volumen1
N.º9
EstadoPublished - sept. 1990
Publicado de forma externa

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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