TY - JOUR
T1 - Preferential retention of paternal alleles in human retinoblastoma
T2 - evidence for genomic imprinting.
AU - Leach, R. J.
AU - Magewu, A. N.
AU - Buckley, J. D.
AU - Benedict, W. F.
AU - Rother, C.
AU - Murphree, A. L.
AU - Griegel, S.
AU - Rajewsky, M. F.
AU - Jones, P. A.
PY - 1990
Y1 - 1990
N2 - The origins of the initial mutations in sporadic retinoblastoma were explored using polymorphic markers from chromosome 13q. The paternal chromosome was maintained in 3 of 3 informative bilateral tumors which had undergone reduction to homozygosity for regions of this chromosome. The paternal chromosome was maintained in 7 of 8 informative unilateral tumors which likewise demonstrated a reduction of homozygosity. These data are in contrast to previously published studies of chromosome retention in unilateral retinoblastoma [Dryja, T. P., Mukai, S., Petersen, R., Rapaport, J. M., Walton, D., and Yandel, D. W. Nature (Lond.), 339: 556-558, 1989; Zhu, Z., Dunn, J. M., Phillips, R. A., Goddard, A. D., Paton, K. E., Becker, A., and Gallie, B. L. Nature (Lond.), 340: 312-313, 1989] and provide the first evidence that genomic imprinting may play a role in this disease.
AB - The origins of the initial mutations in sporadic retinoblastoma were explored using polymorphic markers from chromosome 13q. The paternal chromosome was maintained in 3 of 3 informative bilateral tumors which had undergone reduction to homozygosity for regions of this chromosome. The paternal chromosome was maintained in 7 of 8 informative unilateral tumors which likewise demonstrated a reduction of homozygosity. These data are in contrast to previously published studies of chromosome retention in unilateral retinoblastoma [Dryja, T. P., Mukai, S., Petersen, R., Rapaport, J. M., Walton, D., and Yandel, D. W. Nature (Lond.), 339: 556-558, 1989; Zhu, Z., Dunn, J. M., Phillips, R. A., Goddard, A. D., Paton, K. E., Becker, A., and Gallie, B. L. Nature (Lond.), 340: 312-313, 1989] and provide the first evidence that genomic imprinting may play a role in this disease.
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M3 - Article
C2 - 1981144
AN - SCOPUS:0025492871
SN - 1044-9523
VL - 1
SP - 401
EP - 406
JO - Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research
JF - Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research
IS - 9
ER -