Predictors of outcomes in the treatment of urge urinary incontinence in women

Introduction and hypothesis: Women with urge predominant urinary incontinence received active intervention (drug therapy alone or combined with behavioral therapy) for 10 weeks, then stopped all therapy and were followed for 6 months more. In this planned secondary analysis, we aimed to identify predictors of therapeutic success at 10 weeks (≥70% reduction in incontinence) and of ability to discontinue treatment and sustain improvements 6 months later. Methods: Using data from 307 women, we performed logistic regression to identify predictors for outcomes described above. Results: After controlling for group, only younger age was associated with short-term success (OR 0.8, 95% CI 0.66, 0.96). At 6 months, controlling for group and short-term outcome, only greater anterior vaginal wall prolapse was associated with successful discontinuation (POP-Q point Aa; OR 1.33, 95% CI 1.03, 1.7). Conclusion: These findings are not of sufficient strength to justify withholding conservative therapies but might be used to promote realistic expectations when counseling patients.