Prediction of survival with combining quantitative 18F-FDG PET/CT and DW-MRI parameters in sinonasal malignancies

Kerem Ozturk, Mehmet Gencturk, Emiro Caicedo-Granados, Faqian Li, Zuzan Cayci

Resultado de la investigación: Articlerevisión exhaustiva

5 Citas (Scopus)

Resumen

Background: We aimed to establish the prognostic value of 18F-fluoro-deoxy-glucose positron emission/CT (18F-FDG PET/CT) and diffusion-weighted (DW) MRI in determining overall survival (OS), progression-free survival (PFS), and distant metastasis-free survival (DMFS) of sinonasal malignancies. Methods: Sixty-eight patients with sinonasal cancer who underwent both pretreatment 18F-FDG PET/CT scan and head-neck MRI from January 2009 through August 2017 were retrospectively reviewed. Kaplan-Meier survival analysis of 18F-FDG PET/CT and DW-MRI parameters were performed for OS, PFS, and DMFS. Results: Cox regression analysis determined that all the quantitative 18F-FDG PET/CT and DW-MRI parameters were independently correlated with PFS, DMFS, and OS (P <.05). After controlling for imaging variables, perineural invasion (P =.02) and ill-defined margin (P =.02) were found to be significantly correlated with shorter OS; while the perineural invasion was significantly correlated with shorter PFS (P =.02). Conclusions: The pretreatment DW-MRI and 18F-FDG PET/CT parameters could be substantial surrogate markers for sinonasal malignancies.

Idioma originalEnglish (US)
Páginas (desde-hasta)3080-3089
Número de páginas10
PublicaciónHead and Neck
Volumen41
N.º9
DOI
EstadoPublished - sept. 2019
Publicado de forma externa

ASJC Scopus subject areas

  • Otorhinolaryngology

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