Precision Behavioral Management (PBM): A Novel Genetically Guided Therapy to Combat Reward Deficiency Syndrome (RDS) Relevant to the Opiate Crisis

Kenneth Blum; Alphonse Kenison Roy; Arwen Podesta; Edward J. Modestino; Bruce Steinberg; Marjorie C. Gondré-Lewis; David Baron; Panayotis K. Thanos; Lisa Lott; Sampada Badgaiyan; Jessica Valdez Ponce; Brent Boyett; David Siwicki; Mark Moran; Drew Edwards; Thomas McLaughlin; Eric R. Braverman; Thomas A. Simpatico; Mary Hauser; Bernard William Downs; Rajendra D. Badgaiyan

doi:10.1017/9781108632591.031

Precision Behavioral Management (PBM): A Novel Genetically Guided Therapy to Combat Reward Deficiency Syndrome (RDS) Relevant to the Opiate Crisis

Kenneth Blum
, Alphonse Kenison Roy
, Arwen Podesta
, Edward J. Modestino
, Bruce Steinberg
, Marjorie C. Gondré-Lewis
, David Baron
, Panayotis K. Thanos
, Lisa Lott
, Sampada Badgaiyan
, Jessica Valdez Ponce
, Brent Boyett
, David Siwicki
, Mark Moran
, Drew Edwards
, Thomas McLaughlin
, Eric R. Braverman
, Thomas A. Simpatico
, Mary Hauser
, Bernard William Downs

Rajendra D. Badgaiyan

Department of Psychiatry & Behavioral Sciences

Producción científica: Chapter

3 Citas (Scopus)

Resumen

Reward Deficiency Syndrome (RDS) is an umbrella term for all drug and nondrug addictive behaviors, due to a dopamine deficiency, “hypodopaminergia.” There is an opioid-overdose epidemic in the USA, which may result in or worsen RDS. A paradigm shift is needed to combat a system that is not working. This shift involves the recognition of dopamine homeostasis as the ultimate treatment of RDS via precision, genetically guided KB220 variants, called Precision Behavioral Management (PBM). Recognition of RDS as an endophenotype and an umbrella term in the future DSM 6, following the Research Domain Criteria (RDoC), would assist in shifting this paradigm.

Idioma original	English (US)
Título de la publicación alojada	The Cambridge Handbook of Substance and Behavioral Addictions
Editorial	Cambridge University Press
Páginas	297-306
Número de páginas	10
ISBN (versión digital)	9781108632591
ISBN (versión impresa)	9781108427166
DOI	https://doi.org/10.1017/9781108632591.031
Estado	Published - ene 1 2020

ASJC Scopus subject areas

General Psychology
General Social Sciences
General Medicine

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10.1017/9781108632591.031

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Blum, K., Roy, A. K., Podesta, A., Modestino, E. J., Steinberg, B., Gondré-Lewis, M. C., Baron, D., Thanos, P. K., Lott, L., Badgaiyan, S., Ponce, J. V., Boyett, B., Siwicki, D., Moran, M., Edwards, D., McLaughlin, T., Braverman, E. R., Simpatico, T. A., Hauser, M., ... Badgaiyan, R. D. (2020). Precision Behavioral Management (PBM): A Novel Genetically Guided Therapy to Combat Reward Deficiency Syndrome (RDS) Relevant to the Opiate Crisis. En The Cambridge Handbook of Substance and Behavioral Addictions (pp. 297-306). Cambridge University Press. https://doi.org/10.1017/9781108632591.031

Blum, K, Roy, AK, Podesta, A, Modestino, EJ, Steinberg, B, Gondré-Lewis, MC, Baron, D, Thanos, PK, Lott, L, Badgaiyan, S, Ponce, JV, Boyett, B, Siwicki, D, Moran, M, Edwards, D, McLaughlin, T, Braverman, ER, Simpatico, TA, Hauser, M, Downs, BW & Badgaiyan, RD 2020, Precision Behavioral Management (PBM): A Novel Genetically Guided Therapy to Combat Reward Deficiency Syndrome (RDS) Relevant to the Opiate Crisis. En The Cambridge Handbook of Substance and Behavioral Addictions. Cambridge University Press, pp. 297-306. https://doi.org/10.1017/9781108632591.031

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abstract = "Reward Deficiency Syndrome (RDS) is an umbrella term for all drug and nondrug addictive behaviors, due to a dopamine deficiency, {\textquotedblleft}hypodopaminergia.{\textquotedblright} There is an opioid-overdose epidemic in the USA, which may result in or worsen RDS. A paradigm shift is needed to combat a system that is not working. This shift involves the recognition of dopamine homeostasis as the ultimate treatment of RDS via precision, genetically guided KB220 variants, called Precision Behavioral Management (PBM). Recognition of RDS as an endophenotype and an umbrella term in the future DSM 6, following the Research Domain Criteria (RDoC), would assist in shifting this paradigm.",

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Precision Behavioral Management (PBM): A Novel Genetically Guided Therapy to Combat Reward Deficiency Syndrome (RDS) Relevant to the Opiate Crisis

Resumen

ASJC Scopus subject areas

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