TY - CHAP
T1 - Precision Behavioral Management (PBM)
T2 - A Novel Genetically Guided Therapy to Combat Reward Deficiency Syndrome (RDS) Relevant to the Opiate Crisis
AU - Blum, Kenneth
AU - Roy, Alphonse Kenison
AU - Podesta, Arwen
AU - Modestino, Edward J.
AU - Steinberg, Bruce
AU - Gondré-Lewis, Marjorie C.
AU - Baron, David
AU - Thanos, Panayotis K.
AU - Lott, Lisa
AU - Badgaiyan, Sampada
AU - Ponce, Jessica Valdez
AU - Boyett, Brent
AU - Siwicki, David
AU - Moran, Mark
AU - Edwards, Drew
AU - McLaughlin, Thomas
AU - Braverman, Eric R.
AU - Simpatico, Thomas A.
AU - Hauser, Mary
AU - Downs, Bernard William
AU - Badgaiyan, Rajendra D.
N1 - Publisher Copyright:
© Cambridge University Press 2020.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Reward Deficiency Syndrome (RDS) is an umbrella term for all drug and nondrug addictive behaviors, due to a dopamine deficiency, “hypodopaminergia.” There is an opioid-overdose epidemic in the USA, which may result in or worsen RDS. A paradigm shift is needed to combat a system that is not working. This shift involves the recognition of dopamine homeostasis as the ultimate treatment of RDS via precision, genetically guided KB220 variants, called Precision Behavioral Management (PBM). Recognition of RDS as an endophenotype and an umbrella term in the future DSM 6, following the Research Domain Criteria (RDoC), would assist in shifting this paradigm.
AB - Reward Deficiency Syndrome (RDS) is an umbrella term for all drug and nondrug addictive behaviors, due to a dopamine deficiency, “hypodopaminergia.” There is an opioid-overdose epidemic in the USA, which may result in or worsen RDS. A paradigm shift is needed to combat a system that is not working. This shift involves the recognition of dopamine homeostasis as the ultimate treatment of RDS via precision, genetically guided KB220 variants, called Precision Behavioral Management (PBM). Recognition of RDS as an endophenotype and an umbrella term in the future DSM 6, following the Research Domain Criteria (RDoC), would assist in shifting this paradigm.
KW - Dopamine homeostasis
KW - GARStm
KW - KB220 variants
KW - Pain
KW - Precision Addiction Management
KW - Precision Behavioral Management
KW - Reward Deficiency Syndrome (RDS)
UR - http://www.scopus.com/inward/record.url?scp=85192287894&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85192287894&partnerID=8YFLogxK
U2 - 10.1017/9781108632591.031
DO - 10.1017/9781108632591.031
M3 - Chapter
AN - SCOPUS:85192287894
SN - 9781108427166
SP - 297
EP - 306
BT - The Cambridge Handbook of Substance and Behavioral Addictions
PB - Cambridge University Press
ER -