Potential relationship between inadequate response to dna damage and development of myelodysplastic syndrome

Ting Zhou, Peishuai Chen, Jian Gu, Alexander J.R. Bishop, Linda M. Scott, Paul Hasty, Vivienne I. Rebel

Producción científica: Review articlerevisión exhaustiva

25 Citas (Scopus)

Resumen

Hematopoietic stem cells (HSCs) are responsible for the continuous regeneration of all types of blood cells, including themselves. To ensure the functional and genomic integrity of blood tissue, a network of regulatory pathways tightly controls the proliferative status of HSCs. Nevertheless, normal HSC aging is associated with a noticeable decline in regenerative potential and possible changes in other functions. Myelodysplastic syndrome (MDS) is an age-associated hematopoietic malignancy, characterized by abnormal blood cell maturation and a high propensity for leukemic transformation. It is furthermore thought to originate in a HSC and to be associated with the accrual of multiple genetic and epigenetic aberrations. This raises the question whether MDS is, in part, related to an inability to adequately cope with DNA damage. Here we discuss the various components of the cellular response to DNA damage. For each component, we evaluate related studies that may shed light on a potential relationship between MDS development and aberrant DNA damage response/repair.

Idioma originalEnglish (US)
Páginas (desde-hasta)966-989
Número de páginas24
PublicaciónInternational journal of molecular sciences
Volumen16
N.º1
DOI
EstadoPublished - ene 5 2015

ASJC Scopus subject areas

  • Molecular Biology
  • Spectroscopy
  • Catalysis
  • Inorganic Chemistry
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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