TY - JOUR
T1 - Potential of chemically modified hydrophilic surface characteristics to support tissue integration of titanium dental implants
AU - Schwarz, Frank
AU - Wieland, Marco
AU - Schwartz, Zvi
AU - Zhao, Ge
AU - Rupp, Frank
AU - Geis-Gerstorfer, Jürgen
AU - Schedle, Andreas
AU - Broggini, Nina
AU - Bornstein, Michael M.
AU - Buser, Daniel
AU - Ferguson, Stephen J.
AU - Becker, Jürgen
AU - Boyan, Barbara D.
AU - Cochran, David L.
PY - 2009/2
Y1 - 2009/2
N2 - In the past, several modifications of specific surface properties such as topography, structure, chemistry, surface charge, and wettability have been investigated to predictably improve the osseointegration of titanium implants. The aim of the present review was to evaluate, based on the currently available evidence, the impact of hydrophilic surface modifications of titanium for dental implants. A surface treatment was performed to produce hydroxylated/ hydrated titanium surfaces with identical microstructure to either acid-etched, or sand-blasted, large grit and acid-etched substrates, but with hydrophilic character. Preliminary in vitro studies have indicated that the specific properties noted for hydrophilic titanium surfaces have a significant influence on cell differentiation and growth factor production. Animal experiments have pointed out that hydrophilic surfaces improve early stages of soft tissue and hard tissue integration of either nonsubmerged or submerged titanium implants. This data was also corroborated by the results from preliminary clinical studies. In conclusion, the present review has pointed to a potential of hydrophilic surface modifications to support tissue integration of titanium dental implants.
AB - In the past, several modifications of specific surface properties such as topography, structure, chemistry, surface charge, and wettability have been investigated to predictably improve the osseointegration of titanium implants. The aim of the present review was to evaluate, based on the currently available evidence, the impact of hydrophilic surface modifications of titanium for dental implants. A surface treatment was performed to produce hydroxylated/ hydrated titanium surfaces with identical microstructure to either acid-etched, or sand-blasted, large grit and acid-etched substrates, but with hydrophilic character. Preliminary in vitro studies have indicated that the specific properties noted for hydrophilic titanium surfaces have a significant influence on cell differentiation and growth factor production. Animal experiments have pointed out that hydrophilic surfaces improve early stages of soft tissue and hard tissue integration of either nonsubmerged or submerged titanium implants. This data was also corroborated by the results from preliminary clinical studies. In conclusion, the present review has pointed to a potential of hydrophilic surface modifications to support tissue integration of titanium dental implants.
KW - Biomechanical testing
KW - Histology
KW - Hydrophilicity
KW - Immunohistochemistry
KW - Osteoblast differentiation
KW - Surface chemistry
KW - Surface energy
KW - Titanium implant surfaces
UR - http://www.scopus.com/inward/record.url?scp=60849119835&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=60849119835&partnerID=8YFLogxK
U2 - 10.1002/jbm.b.31233
DO - 10.1002/jbm.b.31233
M3 - Review article
C2 - 18837448
AN - SCOPUS:60849119835
SN - 1552-4973
VL - 88
SP - 544
EP - 557
JO - Journal of Biomedical Materials Research - Part B Applied Biomaterials
JF - Journal of Biomedical Materials Research - Part B Applied Biomaterials
IS - 2
ER -