Polymorphisms identification and associations of KLF7 gene with cattle growth traits

L. Ma; Y. J. Qu; Y. T. Huai; Z. J. Li; J. Wang; X. Y. Lan; C. L. Zhang; J. Q. Wang; H. Chen

doi:10.1016/j.livsci.2010.04.014

Polymorphisms identification and associations of KLF7 gene with cattle growth traits

L. Ma, Y. J. Qu, Y. T. Huai, Z. J. Li, J. Wang, X. Y. Lan, C. L. Zhang, J. Q. Wang, H. Chen

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19 Citas (Scopus)

Resumen

The Kruppel-like factor KLF7 gene was studied as a candidate for genetic markers of growth traits. We investigated the growth traits at different ages of 1002 Chinese cattles belonging to four breeds and applied artificially created restriction site (ACRS)-PCR-RFLP and DNA sequencing methods to reveal three SNPs: NC_007300:g.41401C>T (p.F54F), 42025T>C and 42075A>G. The statistical results indicated there was a strong linkage not only between C41401T and T42025C in Jiaxian, but also between T42025C and A42075G in Qinchuan, Nanyang and Chinese Holstein respectively (r²>0.33). Significant statistical differences in genotypic frequencies at the three loci displayed that the polymorphisms were remarkably correlated with cattle breeds by Χ² test (P<0.001). In addition, the cattle with genotype T₂T₂, C₂C₂ (T42025C), A₃A₃ (A42075G), haplotype C₁C₁C₂C₂A₃A₃ and C₁T₁T₂C₂A₃G₃ showed better growth traits (P<0.01). The biochemical and physiological functions, together with the results obtained in our investigation, suggest that the KLF7 gene might play important roles affecting growth traits in cattle.

Idioma original	English (US)
Páginas (desde-hasta)	1-7
Número de páginas	7
Publicación	Livestock Science
Volumen	135
N.º	1
DOI	https://doi.org/10.1016/j.livsci.2010.04.014
Estado	Published - ene 2011
Publicado de forma externa	Sí

ASJC Scopus subject areas

Animal Science and Zoology
General Veterinary

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10.1016/j.livsci.2010.04.014

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@article{969afcb86b184ac7874c377223eef9d3,

title = "Polymorphisms identification and associations of KLF7 gene with cattle growth traits",

abstract = "The Kruppel-like factor KLF7 gene was studied as a candidate for genetic markers of growth traits. We investigated the growth traits at different ages of 1002 Chinese cattles belonging to four breeds and applied artificially created restriction site (ACRS)-PCR-RFLP and DNA sequencing methods to reveal three SNPs: NC_007300:g.41401C>T (p.F54F), 42025T>C and 42075A>G. The statistical results indicated there was a strong linkage not only between C41401T and T42025C in Jiaxian, but also between T42025C and A42075G in Qinchuan, Nanyang and Chinese Holstein respectively (r2>0.33). Significant statistical differences in genotypic frequencies at the three loci displayed that the polymorphisms were remarkably correlated with cattle breeds by Χ2 test (P<0.001). In addition, the cattle with genotype T2T2, C2C2 (T42025C), A3A3 (A42075G), haplotype C1C1C2C2A3A3 and C1T1T2C2A3G3 showed better growth traits (P<0.01). The biochemical and physiological functions, together with the results obtained in our investigation, suggest that the KLF7 gene might play important roles affecting growth traits in cattle.",

keywords = "Cattle, Growth traits, KLF7 gene, PCR-RFLP, Single nucleotide polymorphism",

author = "L. Ma and Qu, {Y. J.} and Huai, {Y. T.} and Li, {Z. J.} and J. Wang and Lan, {X. Y.} and Zhang, {C. L.} and Wang, {J. Q.} and H. Chen",

note = "Funding Information: This study was supported by the National 863 Program of China (nos. 2006AA10Z197 and 2008AA101010 ), National Natural Science Foundation of China (nos. 30771544 and 30972080 ), National Key Technology R&D Program (no. 2006BAD01A10-5 ), Keystone Project of transfergene in China ( 2009ZX08009-157B and 2008ZX08007-002 ), “13115” Sci-Tech Innovation Program of Shaanxi Province ( 2008ZDKG-11 ), Program of National Beef Cattle Industrial Technology System, Basic and Foreland Technology Study Program of Henan Province (no. 072300430160 ). ",

year = "2011",

month = jan,

doi = "10.1016/j.livsci.2010.04.014",

language = "English (US)",

volume = "135",

pages = "1--7",

journal = "Livestock Science",

issn = "1871-1413",

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T1 - Polymorphisms identification and associations of KLF7 gene with cattle growth traits

AU - Ma, L.

AU - Qu, Y. J.

AU - Huai, Y. T.

AU - Li, Z. J.

AU - Wang, J.

AU - Lan, X. Y.

AU - Zhang, C. L.

AU - Wang, J. Q.

AU - Chen, H.

N1 - Funding Information: This study was supported by the National 863 Program of China (nos. 2006AA10Z197 and 2008AA101010 ), National Natural Science Foundation of China (nos. 30771544 and 30972080 ), National Key Technology R&D Program (no. 2006BAD01A10-5 ), Keystone Project of transfergene in China ( 2009ZX08009-157B and 2008ZX08007-002 ), “13115” Sci-Tech Innovation Program of Shaanxi Province ( 2008ZDKG-11 ), Program of National Beef Cattle Industrial Technology System, Basic and Foreland Technology Study Program of Henan Province (no. 072300430160 ).

PY - 2011/1

Y1 - 2011/1

N2 - The Kruppel-like factor KLF7 gene was studied as a candidate for genetic markers of growth traits. We investigated the growth traits at different ages of 1002 Chinese cattles belonging to four breeds and applied artificially created restriction site (ACRS)-PCR-RFLP and DNA sequencing methods to reveal three SNPs: NC_007300:g.41401C>T (p.F54F), 42025T>C and 42075A>G. The statistical results indicated there was a strong linkage not only between C41401T and T42025C in Jiaxian, but also between T42025C and A42075G in Qinchuan, Nanyang and Chinese Holstein respectively (r2>0.33). Significant statistical differences in genotypic frequencies at the three loci displayed that the polymorphisms were remarkably correlated with cattle breeds by Χ2 test (P<0.001). In addition, the cattle with genotype T2T2, C2C2 (T42025C), A3A3 (A42075G), haplotype C1C1C2C2A3A3 and C1T1T2C2A3G3 showed better growth traits (P<0.01). The biochemical and physiological functions, together with the results obtained in our investigation, suggest that the KLF7 gene might play important roles affecting growth traits in cattle.

AB - The Kruppel-like factor KLF7 gene was studied as a candidate for genetic markers of growth traits. We investigated the growth traits at different ages of 1002 Chinese cattles belonging to four breeds and applied artificially created restriction site (ACRS)-PCR-RFLP and DNA sequencing methods to reveal three SNPs: NC_007300:g.41401C>T (p.F54F), 42025T>C and 42075A>G. The statistical results indicated there was a strong linkage not only between C41401T and T42025C in Jiaxian, but also between T42025C and A42075G in Qinchuan, Nanyang and Chinese Holstein respectively (r2>0.33). Significant statistical differences in genotypic frequencies at the three loci displayed that the polymorphisms were remarkably correlated with cattle breeds by Χ2 test (P<0.001). In addition, the cattle with genotype T2T2, C2C2 (T42025C), A3A3 (A42075G), haplotype C1C1C2C2A3A3 and C1T1T2C2A3G3 showed better growth traits (P<0.01). The biochemical and physiological functions, together with the results obtained in our investigation, suggest that the KLF7 gene might play important roles affecting growth traits in cattle.

KW - Cattle

KW - Growth traits

KW - KLF7 gene

KW - PCR-RFLP

KW - Single nucleotide polymorphism

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DO - 10.1016/j.livsci.2010.04.014

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SN - 1871-1413

VL - 135

SP - 1

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JO - Livestock Science

JF - Livestock Science

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Polymorphisms identification and associations of KLF7 gene with cattle growth traits

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