PML-RARA fusion resulting from a cryptic insertion of RARA gene into PML gene without the reciprocal RARA-PML fusion: Clinical, cytogenetic, and molecular characterization and prognosis

Hongxin Fan, Veronica Ortega, Hilal M. Fanasch, Yao Wang, Kenneth N. Holder, Russell A. Higgins, Christina Mendiola, Gihan Mohamed, Kumari Vadlamudi, Gopalrao Velagaleti

Producción científica: Articlerevisión exhaustiva

5 Citas (Scopus)

Resumen

We describe a case of acute promyelocytic leukemia in a 61-yr-old woman with a cryptic insertion of RARA gene into PML gene. Using a combination of cytogenetic and molecular methods, we confirmed the insertion and presence of the PML-RARA transcript and lack of the reciprocal RARA-PML transcript. Although such cryptic insertions leading to a PML-RARA fusion have been previously reported, we show that such variant insertions, based on our case, appear to have the same prognostic significance as the classical t(15;17)(q22;q21).

Idioma originalEnglish (US)
Páginas (desde-hasta)354-358
Número de páginas5
PublicaciónEuropean Journal of Haematology
Volumen93
N.º4
DOI
EstadoPublished - 2014

ASJC Scopus subject areas

  • Hematology

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