Platelet 3H-imipramine uptake receptor density and serum serotonin levels in patients with fibromyalgia/fibrositis syndrome

I. J. Russell, J. E. Michalek, G. A. Vipraio, E. M. Fletcher, M. A. Javors, Charles L Bowden

Producción científica: Articlerevisión exhaustiva

239 Citas (Scopus)

Resumen

The density of serotonin reuptake receptors on peripheral platelets from 22 patients with primary fibromyalgia syndrome (FS) and the serum serotonin concentrations in 9 patients with FS were compared with those of matched healthy controls. The mean serum serotonin concentration was lower (p = 0.01) in FS than in controls, while the binding of 3H-imipramine was higher (p = 0.035) and normalized with treatment using a combination of ibuprofen and alprazolam. Improvement in selected clinical measures of FS disease activity during treatment correlated with the change in platelet 3H-imipramine binding. These findings support the proposed hypothesis of aberrant pain perception in FS resulting from a deficiency of serotonin.

Idioma originalEnglish (US)
Páginas (desde-hasta)104-109
Número de páginas6
PublicaciónJournal of Rheumatology
Volumen19
N.º1
EstadoPublished - ene 1 1992

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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