TY - JOUR
T1 - Plasma levels of soluble tumor necrosis factor receptors are associated with cognitive performance in Parkinson's disease
AU - Rocha, Natália Pessoa
AU - Teixeira, Antônio Lúcio
AU - Scalzo, Paula Luciana
AU - Barbosa, Izabela Guimarães
AU - de Sousa, Mariana Soares
AU - Morato, Isabela Boechat
AU - Vieira, Érica Leandro Marciano
AU - Christo, Paulo Pereira
AU - Palotás, András
AU - Reis, Helton José
PY - 2014/4
Y1 - 2014/4
N2 - Inflammatory mechanisms have been implicated in a series of neuropsychiatric conditions, including behavioral disturbances, cognitive dysfunction, and affective disorders. Accumulating evidence also strongly suggests their involvement in the pathophysiology of Parkinson's disease (PD). This study aimed to evaluate plasma levels of inflammatory biomarkers, and their association with cognitive performance and other non-motor symptoms of PD. PD patients and control individuals were subjected to various psychometric tests, including the Mini-Mental State Examination (MMSE), Frontal Assessment Battery (FAB), and Beck's Depression Inventory (BDI). Biomarker plasma levels were measured by enzyme-linked immunosorbent assay (ELISA). PD patients exhibited worse performance on MMSE and the programming task of FAB, and presented higher soluble tumor necrosis factor receptor (sTNFR) plasma levels than control individuals. Among PD patients, increased sTNFR1 and sTNFR2 concentrations were associated with poorer cognitive test scores. After multiple linear regression, sTNFR1 and education remained a significant predictor for FAB scores. Our data suggest that PD is associated with a proinflammatory profile, and sTNFRs are putative biomarkers of cognitive performance, with elevated sTNFR1 levels predicting poorer executive functioning in PD patients.
AB - Inflammatory mechanisms have been implicated in a series of neuropsychiatric conditions, including behavioral disturbances, cognitive dysfunction, and affective disorders. Accumulating evidence also strongly suggests their involvement in the pathophysiology of Parkinson's disease (PD). This study aimed to evaluate plasma levels of inflammatory biomarkers, and their association with cognitive performance and other non-motor symptoms of PD. PD patients and control individuals were subjected to various psychometric tests, including the Mini-Mental State Examination (MMSE), Frontal Assessment Battery (FAB), and Beck's Depression Inventory (BDI). Biomarker plasma levels were measured by enzyme-linked immunosorbent assay (ELISA). PD patients exhibited worse performance on MMSE and the programming task of FAB, and presented higher soluble tumor necrosis factor receptor (sTNFR) plasma levels than control individuals. Among PD patients, increased sTNFR1 and sTNFR2 concentrations were associated with poorer cognitive test scores. After multiple linear regression, sTNFR1 and education remained a significant predictor for FAB scores. Our data suggest that PD is associated with a proinflammatory profile, and sTNFRs are putative biomarkers of cognitive performance, with elevated sTNFR1 levels predicting poorer executive functioning in PD patients.
KW - Cognition
KW - Inflammation
KW - Non-motor symptoms
KW - Parkinson's disease
KW - Tumor necrosis factor
UR - http://www.scopus.com/inward/record.url?scp=84898058393&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84898058393&partnerID=8YFLogxK
U2 - 10.1002/mds.25752
DO - 10.1002/mds.25752
M3 - Article
C2 - 24301904
AN - SCOPUS:84898058393
SN - 0885-3185
VL - 29
SP - 527
EP - 531
JO - Movement Disorders
JF - Movement Disorders
IS - 4
ER -