TY - JOUR
T1 - Pilot Study on the Impact of a Home-Based Exercise Program on Inflammatory Cytokines and Quality of Life in Men with Prostate Cancer Under Active Surveillance
AU - Moon, Crisann
AU - Gallegos, Amber M.
AU - Sheikh, Bilal
AU - Kumar, Pratap
AU - Liss, Michael
AU - Patel, Darpan I.
N1 - Funding Information:
This study was funded by an internal research grant from the School of Nursing Advisory Council at the University of Texas Health Science Center and a grant from the United States Department of Education (P031S150048). The National Cancer Institute designated UT Health San Antonio Mays Cancer Center also supported this work (P30CA54174OD).
Funding Information:
The authors would like to thank the men who volunteered their time and effort for this study. Without willing volunteers like the participants in the study, we would never be able to understand the clinical impact of exercise. The authors would also like to acknowledge the Bioanalytics and Single-Cell (BASiC) Core at UT Health San Antonio’s Greehy Children’s Cancer Research Institute in support of the multiplex analysis performed for this study. This study was funded by an internal research grant from the School of Nursing Advisory Council at the University of Texas Health Science Center and a grant from the United States Department of Education (P031S150048). The National Cancer Institute designated UT Health San Antonio Mays Cancer Center also supported this work (P30CA54174OD).
Publisher Copyright:
© The Author(s) 2022.
PY - 2022/9
Y1 - 2022/9
N2 - Objectives: This study aimed to demonstrate potential translation of pre-clinical studies to a home-based exercise intervention in mediating inflammatory cytokine markers and tumor progression in men under active surveillance for prostate cancer. Methods: A 2-arm randomized control parallel group design was used. The exercise intervention consisted of 24 weeks of an aerobic and resistance home-based exercise program and results were compared to a waitlist control group. Data were collected at baseline and end of study for eotaxin, interferon-γ (INF-γ), interleukin-12 (IL-12), interleukin-1α (IL-1α), interleukin-5 (IL-5), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and vascular endothelial growth factor (VEGF), distanced walked during a 6-minute walk test (6MWT), body mass index, and health-related quality of life. Results: Non-significant decreases were observed in all biomarkers, especially VEGF (pre: 125.16 ± 198.66, post: 80.29 ± 124.30, P =.06) and INF-γ (pre: 152.88 ± 312.71, post: 118.93 ± 158.79, P =.08), in the intervention group; only IL- α (pre: 332.15 ± 656.77, post: 255.12 ± 502.09, P =.20) decreased in the control group while all other biomarkers increased from baseline to end of study. A non-significant increase in 6MWT distance was observed in the intervention group, while a decrease was seen in the control group. Significant decreases in physical function, emotional wellbeing, and total composite scale on the FACIT-F were observed in the intervention group, possibly due to the isolation restrictions of COVID-19. Physical function on the SF-36 significantly increased in the control group. Conclusions: Future studies with powered samples are needed to confirm the trends observed for inflammatory biomarkers and functional fitness.
AB - Objectives: This study aimed to demonstrate potential translation of pre-clinical studies to a home-based exercise intervention in mediating inflammatory cytokine markers and tumor progression in men under active surveillance for prostate cancer. Methods: A 2-arm randomized control parallel group design was used. The exercise intervention consisted of 24 weeks of an aerobic and resistance home-based exercise program and results were compared to a waitlist control group. Data were collected at baseline and end of study for eotaxin, interferon-γ (INF-γ), interleukin-12 (IL-12), interleukin-1α (IL-1α), interleukin-5 (IL-5), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and vascular endothelial growth factor (VEGF), distanced walked during a 6-minute walk test (6MWT), body mass index, and health-related quality of life. Results: Non-significant decreases were observed in all biomarkers, especially VEGF (pre: 125.16 ± 198.66, post: 80.29 ± 124.30, P =.06) and INF-γ (pre: 152.88 ± 312.71, post: 118.93 ± 158.79, P =.08), in the intervention group; only IL- α (pre: 332.15 ± 656.77, post: 255.12 ± 502.09, P =.20) decreased in the control group while all other biomarkers increased from baseline to end of study. A non-significant increase in 6MWT distance was observed in the intervention group, while a decrease was seen in the control group. Significant decreases in physical function, emotional wellbeing, and total composite scale on the FACIT-F were observed in the intervention group, possibly due to the isolation restrictions of COVID-19. Physical function on the SF-36 significantly increased in the control group. Conclusions: Future studies with powered samples are needed to confirm the trends observed for inflammatory biomarkers and functional fitness.
KW - active surveillance
KW - biomarker
KW - exercise
KW - prostate cancer
KW - quality of life
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U2 - 10.1177/10732748221130964
DO - 10.1177/10732748221130964
M3 - Article
C2 - 36200522
AN - SCOPUS:85139292627
SN - 1073-2748
VL - 29
JO - Cancer Control
JF - Cancer Control
ER -