Phosphoinositide lipid second messengers: New paradigms for calcium channel modulation

Patrick Delmas; Bertrand Coste; Nikita Gamper; Mark S. Shapiro

doi:10.1016/j.neuron.2005.07.001

Phosphoinositide lipid second messengers: New paradigms for calcium channel modulation

Patrick Delmas
, Bertrand Coste
, Nikita Gamper
, Mark S. Shapiro

Department of Cellular & Integrative Physiology

Producción científica: Short survey › revisión exhaustiva

90 Citas (Scopus)

Resumen

Neuronal Ca²⁺ channels are key transducers coupling excitability to cellular function. As such, they are tightly regulated by multiple G protein-signaling pathways that finely tune their activity. In addition to fast, direct Gβγ modulation of Ca²⁺ channels, a slower Gα_q/11-mediated mechanism has remained enigmatic despite intensive study. Recent work suggests that membrane phosphoinositides are crucial determinants of Ca²⁺ channel activity. Here, we discuss their role in Ca²⁺ channel modulation and the leading theories that seek to elucidate the underlying molecular details of the so-called "mysterious" G_q/11-mediated signal.

Idioma original	English (US)
Páginas (desde-hasta)	179-182
Número de páginas	4
Publicación	Neuron
Volumen	47
N.º	2
DOI	https://doi.org/10.1016/j.neuron.2005.07.001
Estado	Published - jul 21 2005

ASJC Scopus subject areas

General Neuroscience

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title = "Phosphoinositide lipid second messengers: New paradigms for calcium channel modulation",

abstract = "Neuronal Ca2+ channels are key transducers coupling excitability to cellular function. As such, they are tightly regulated by multiple G protein-signaling pathways that finely tune their activity. In addition to fast, direct Gβγ modulation of Ca2+ channels, a slower Gαq/11-mediated mechanism has remained enigmatic despite intensive study. Recent work suggests that membrane phosphoinositides are crucial determinants of Ca2+ channel activity. Here, we discuss their role in Ca2+ channel modulation and the leading theories that seek to elucidate the underlying molecular details of the so-called {"}mysterious{"} Gq/11-mediated signal.",

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AU - Coste, Bertrand

AU - Gamper, Nikita

AU - Shapiro, Mark S.

PY - 2005/7/21

Y1 - 2005/7/21

N2 - Neuronal Ca2+ channels are key transducers coupling excitability to cellular function. As such, they are tightly regulated by multiple G protein-signaling pathways that finely tune their activity. In addition to fast, direct Gβγ modulation of Ca2+ channels, a slower Gαq/11-mediated mechanism has remained enigmatic despite intensive study. Recent work suggests that membrane phosphoinositides are crucial determinants of Ca2+ channel activity. Here, we discuss their role in Ca2+ channel modulation and the leading theories that seek to elucidate the underlying molecular details of the so-called "mysterious" Gq/11-mediated signal.

AB - Neuronal Ca2+ channels are key transducers coupling excitability to cellular function. As such, they are tightly regulated by multiple G protein-signaling pathways that finely tune their activity. In addition to fast, direct Gβγ modulation of Ca2+ channels, a slower Gαq/11-mediated mechanism has remained enigmatic despite intensive study. Recent work suggests that membrane phosphoinositides are crucial determinants of Ca2+ channel activity. Here, we discuss their role in Ca2+ channel modulation and the leading theories that seek to elucidate the underlying molecular details of the so-called "mysterious" Gq/11-mediated signal.

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M3 - Short survey

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AN - SCOPUS:22544474377

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EP - 182

JO - Neuron

JF - Neuron

IS - 2

ER -

Phosphoinositide lipid second messengers: New paradigms for calcium channel modulation

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