TY - CHAP
T1 - Phosphatidylethanol homologs in blood as biomarkers for the time frame and amount of recent alcohol consumption
AU - Hill-Kapturczak, Nathalie
AU - Dougherty, Donald M.
AU - Roache, John D.
AU - Karns-Wright, Tara E.
AU - Lopez-Cruzan, Marisa
AU - Javors, Martin A.
N1 - Publisher Copyright:
© 2019 Elsevier Inc. All rights reserved.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Phosphatidylethanol (PEth) is a minor metabolite of ethanol, a phospholipid that is synthesized, stored in membranes of red blood cells (RBCs), and measured in whole blood samples. A unique feature of its pharmacokinetics in RBCs is the lack of a critical catabolic enzyme, which is unlike all other cell types studied. The elimination half-life of PEth is 4-7 days, which provides a window of detection up to 28 days during abstinence. Using high-performance liquid chromatography with tandem mass spectroscopic detection, PEth levels can be detected in whole blood samples even after a single standard alcohol drink (14 g ethanol). There are 48 known homologs of PEth in RBCs. PEth 16:0/18:1 is predominant, representing about 37% of total PEth. PEth 16:0/18:2 and 16:0/20:4 are additional homologs with different pharmacokinetic characteristics to more accurately estimate amount and time frame of alcohol consumption.
AB - Phosphatidylethanol (PEth) is a minor metabolite of ethanol, a phospholipid that is synthesized, stored in membranes of red blood cells (RBCs), and measured in whole blood samples. A unique feature of its pharmacokinetics in RBCs is the lack of a critical catabolic enzyme, which is unlike all other cell types studied. The elimination half-life of PEth is 4-7 days, which provides a window of detection up to 28 days during abstinence. Using high-performance liquid chromatography with tandem mass spectroscopic detection, PEth levels can be detected in whole blood samples even after a single standard alcohol drink (14 g ethanol). There are 48 known homologs of PEth in RBCs. PEth 16:0/18:1 is predominant, representing about 37% of total PEth. PEth 16:0/18:2 and 16:0/20:4 are additional homologs with different pharmacokinetic characteristics to more accurately estimate amount and time frame of alcohol consumption.
KW - PEth 16:0/18:1
KW - PEth 16:0/18:2
KW - PEth 16:0/20:4
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U2 - 10.1016/B978-0-12-813125-1.00058-1
DO - 10.1016/B978-0-12-813125-1.00058-1
M3 - Chapter
AN - SCOPUS:85075494584
SN - 9780128131268
SP - 567
EP - 576
BT - Neuroscience of Alcohol
PB - Elsevier
ER -