Pharmacological Manipulation of Kv7 Channels as a New Therapeutic Tool for Multiple Brain Disorders

Fabio A. Vigil, Chase M. Carver, Mark S. Shapiro

Resultado de la investigación: Review articlerevisión exhaustiva

13 Citas (Scopus)


Kv7 (“M-type,” KCNQ) K+ currents, play dominant roles in controlling neuronal excitability. They act as a “brake” against hyperexcitable states in the central and peripheral nervous systems. Pharmacological augmentation of M current has been developed for controlling epileptic seizures, although current pharmacological tools are uneven in practical usefulness. Lately, however, M-current “opener” compounds have been suggested to be efficacious in preventing brain damage after multiple types of insults/diseases, such as stroke, traumatic brain injury, drug addiction and mood disorders. In this review, we will discuss what is known to date on these efforts and identify gaps in our knowledge regarding the link between M current and therapeutic potential for these disorders. We will outline the preclinical experiments that are yet to be performed to demonstrate the likelihood of success of this approach in human trials. Finally, we also address multiple pharmacological tools available to manipulate different Kv7 subunits and the relevant evidence for translational application in the clinical use for disorders of the central nervous system and multiple types of brain insults. We feel there to be great potential for manipulation of Kv7 channels as a novel therapeutic mode of intervention in the clinic, and that the paucity of existing therapies obligates us to perform further research, so that patients can soon benefit from such therapeutic approaches.

Idioma originalEnglish (US)
Número de artículo688
PublicaciónFrontiers in Physiology
EstadoPublished - jun 19 2020

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


Profundice en los temas de investigación de 'Pharmacological Manipulation of Kv7 Channels as a New Therapeutic Tool for Multiple Brain Disorders'. En conjunto forman una huella única.

Citar esto