Pharmacokinetics of liposomal amphotericin B in pleural fluid

Brad Moriyama, Parizad Torabi-Parizi, Alexandra K. Pratt, Stacey A. Henning, Gennethel Pennick, Yvonne R. Shea, Sinchita Roy Chowdhuri, Michael G. Rinaldi, A. John Barrett, Thomas J. Walsh

Resultado de la investigación: Articlerevisión exhaustiva

19 Citas (Scopus)

Resumen

We report the penetration of liposomal amphotericin B into the pleural fluid of a patient with pulmonary zygomycosis and empyema. The ratio of area under the concentration-versus-time curve in pleural fluid (AUC pleural fluid) to that in serum (AUCserum) for liposomal amphotericin B over 24 h was 9.4%, with pleural fluid concentrations of 2.12 to 4.91 μg/ml. Given the relatively low level of intrapleural penetration of liposomal amphotericin B, chest tube drainage may be warranted for successful treatment of zygomycotic empyema.

Idioma originalEnglish (US)
Páginas (desde-hasta)1633-1635
Número de páginas3
PublicaciónAntimicrobial agents and chemotherapy
Volumen54
N.º4
DOI
EstadoPublished - abr 2010
Publicado de forma externa

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Huella

Profundice en los temas de investigación de 'Pharmacokinetics of liposomal amphotericin B in pleural fluid'. En conjunto forman una huella única.

Citar esto