TY - JOUR
T1 - Peripheral levels of sST2 are increased in patients with temporal lobe epilepsy
T2 - Additional evidence of low-grade inflammation
AU - Toscano, Eliana Cristina de Brito
AU - Lessa, João Marcelo Korcsik
AU - de Oliveira, Guilherme Nogueira
AU - Gonçalves, Ana Paula
AU - Vieira, Érica Leandro Marciano
AU - Rachid, Milene Alvarenga
AU - Teixeira, Antônio Lúcio
N1 - Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/11
Y1 - 2020/11
N2 - Inflammation plays a pivotal role in temporal lobe epilepsy (TLE) pathophysiology. IL-33 can act as a transcription factor or as a cytokine, the latter through the transmembrane ST2 receptor or its soluble isoform (sST2), presenting a dual role in neurological diseases. The aim of this study was to determine the plasma levels of IL-33 and sST2 in parallel with clinical features in patients with TLE. Peripheral blood from patients and controls was sampled for the measurement of plasma levels of IL-33 and sST2 by enzyme-linked immunoassay (ELISA). While there were similar levels of IL-33 between controls and patients, sST2 were increased in patients. IL33 and sST2 plasma levels were not associated with TLE-related clinical features. In a subgroup analysis, IL-33 levels correlated with memory performance. In conclusion, our results reinforce the concept of chronic low-grade inflammation in patients with TLE.
AB - Inflammation plays a pivotal role in temporal lobe epilepsy (TLE) pathophysiology. IL-33 can act as a transcription factor or as a cytokine, the latter through the transmembrane ST2 receptor or its soluble isoform (sST2), presenting a dual role in neurological diseases. The aim of this study was to determine the plasma levels of IL-33 and sST2 in parallel with clinical features in patients with TLE. Peripheral blood from patients and controls was sampled for the measurement of plasma levels of IL-33 and sST2 by enzyme-linked immunoassay (ELISA). While there were similar levels of IL-33 between controls and patients, sST2 were increased in patients. IL33 and sST2 plasma levels were not associated with TLE-related clinical features. In a subgroup analysis, IL-33 levels correlated with memory performance. In conclusion, our results reinforce the concept of chronic low-grade inflammation in patients with TLE.
KW - IL-33
KW - Memory
KW - Neuroinflammation
KW - Temporal lobe epilepsy
KW - sST2
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U2 - 10.1016/j.yebeh.2020.107351
DO - 10.1016/j.yebeh.2020.107351
M3 - Article
C2 - 32846307
AN - SCOPUS:85089725544
SN - 1525-5050
VL - 112
JO - Epilepsy and Behavior
JF - Epilepsy and Behavior
M1 - 107351
ER -