Perioperative complications in patients undergoing major liver resection with or without neoadjuvant chemotherapy

Alexander A. Parikh, Bernhard Gentner, Tsung Teh Wu, Steven A. Curley, Lee M. Ellis, Jean Nicolas Vauthey

Producción científica: Articlerevisión exhaustiva

187 Citas (Scopus)


Systemic chemotherapy is used increasingly prior to resection of hepatic colorectal metastases. Previous reports have indicated an increased risk of perioperative complications associated with the use of systemic chemotherapy prior to resection. The purpose of this study was to investigate perioperative complications in patients receiving neoadjuvant systemic chemotherapy consisting of 5-fluorouracil (5-FU) and leucovorin (LV) with or without CPT-11 within 6 months of major liver resection. A retrospective review of 108 patients undergoing major liver resection for colorectal metastases with curative intent from 1997 to 2002 was performed. Patient and tumor characteristics, perioperative parameters, and morbidity and mortality were measured. Forty-seven patients (44%) received no chemotherapy, 27 patients (25%) received systemic 5-FU/LV, and 34 (31%) received systemic 5-FU/LV/CPT-11. A significantly higher number of patients in the group treated with preoperative 5-FU/LV plus CPT-11 had multiple tumors. Patients in this group also tended to have smaller tumors, fewer complications, and a higher R0 margin resection rate, but these findings were not statistically significant. Median blood loss and length of hospital stay were also not significantly different. There were no perioperative deaths. We conclude that the use of fluoropyrimidine-based chemotherapy and CPT-11 prior to major liver resection is not associated with increased morbidity or mortality. It may therefore provide a better therapeutic option, particularly in patients with multiple colorectal metastases.

Idioma originalEnglish (US)
Páginas (desde-hasta)1082-1088
Número de páginas7
PublicaciónJournal of Gastrointestinal Surgery
EstadoPublished - dic 1 2003
Publicado de forma externa

ASJC Scopus subject areas

  • Gastroenterology
  • Surgery


Profundice en los temas de investigación de 'Perioperative complications in patients undergoing major liver resection with or without neoadjuvant chemotherapy'. En conjunto forman una huella única.

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