PD-1 inhibition achieves a complete metabolic response in a patient with malignant peripheral nerve sheath tumor

Lisa E. Davis, Lauren A. Nicholls, Hani M. Babiker, Joy Liau, Daruka Mahadevan

Producción científica: Articlerevisión exhaustiva

17 Citas (Scopus)

Resumen

High-grade malignant peripheral nerve sheath tumors (MPNST) have a poor prognosis with limited responsiveness to systemic therapy. We document a case of a complete metabolic response to pembrolizumab monotherapy in metastatic disease. Tumor molecular profiling identified programmed-death ligand-1 (PD-L1) positivity. This characteristic provided a rationale for immune-checkpoint therapy. Treatment with pembrolizumab resulted in a complete metabolic response after four cycles of therapy. Patients with PD-L1–positive, metastatic MPNST may be candidates for immune-checkpoint therapy, which may produce a durable complete remission. Future study of anti–PD-1/PD-L1 therapy is warranted.

Idioma originalEnglish (US)
Páginas (desde-hasta)1396-1400
Número de páginas5
PublicaciónCancer Immunology Research
Volumen7
N.º9
DOI
EstadoPublished - 2019
Publicado de forma externa

ASJC Scopus subject areas

  • General Medicine

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