Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity

Mengle Shao; Chelsea Hepler; Qianbin Zhang; Bo Shan; Lavanya Vishvanath; Gervaise H. Henry; Shangang Zhao; Yu A. An; Yibo Wu; Douglas W. Strand; Rana K. Gupta

doi:10.1016/j.stem.2020.12.008

Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity

Mengle Shao, Chelsea Hepler, Qianbin Zhang, Bo Shan, Lavanya Vishvanath, Gervaise H. Henry, Shangang Zhao, Yu A. An, Yibo Wu, Douglas W. Strand, Rana K. Gupta

Producción científica: Article › revisión exhaustiva

66 Citas (Scopus)

Resumen

How adipocyte precursor cells are regulated to control depot-specific adipose tissue expansion in obesity remains unclear. Here, Shao et al. identify a HIFα-dependent regulatory mechanism controlling adipocyte progenitor activity in mice and demonstrate the ability of the anti-cancer drug Imatinib to promote metabolically beneficial adipogenesis in obesity.

Idioma original	English (US)
Páginas (desde-hasta)	685-701.e7
Publicación	Cell Stem Cell
Volumen	28
N.º	4
DOI	https://doi.org/10.1016/j.stem.2020.12.008
Estado	Published - abr 1 2021

ASJC Scopus subject areas

Molecular Medicine
Genetics
Cell Biology

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10.1016/j.stem.2020.12.008

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title = "Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity",

abstract = "How adipocyte precursor cells are regulated to control depot-specific adipose tissue expansion in obesity remains unclear. Here, Shao et al. identify a HIFα-dependent regulatory mechanism controlling adipocyte progenitor activity in mice and demonstrate the ability of the anti-cancer drug Imatinib to promote metabolically beneficial adipogenesis in obesity.",

keywords = "Adipocyte precursor cell, Adipogenesis, Fibrosis, HIF1α, Imatinib, PDGFR, PPARγ",

author = "Mengle Shao and Chelsea Hepler and Qianbin Zhang and Bo Shan and Lavanya Vishvanath and Henry, {Gervaise H.} and Shangang Zhao and An, {Yu A.} and Yibo Wu and Strand, {Douglas W.} and Gupta, {Rana K.}",

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T1 - Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity

AU - Shao, Mengle

AU - Hepler, Chelsea

AU - Zhang, Qianbin

AU - Shan, Bo

AU - Vishvanath, Lavanya

AU - Henry, Gervaise H.

AU - Zhao, Shangang

AU - An, Yu A.

AU - Wu, Yibo

AU - Strand, Douglas W.

AU - Gupta, Rana K.

PY - 2021/4/1

Y1 - 2021/4/1

N2 - How adipocyte precursor cells are regulated to control depot-specific adipose tissue expansion in obesity remains unclear. Here, Shao et al. identify a HIFα-dependent regulatory mechanism controlling adipocyte progenitor activity in mice and demonstrate the ability of the anti-cancer drug Imatinib to promote metabolically beneficial adipogenesis in obesity.

AB - How adipocyte precursor cells are regulated to control depot-specific adipose tissue expansion in obesity remains unclear. Here, Shao et al. identify a HIFα-dependent regulatory mechanism controlling adipocyte progenitor activity in mice and demonstrate the ability of the anti-cancer drug Imatinib to promote metabolically beneficial adipogenesis in obesity.

KW - Adipocyte precursor cell

KW - Adipogenesis

KW - Fibrosis

KW - HIF1α

KW - Imatinib

KW - PDGFR

KW - PPARγ

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SN - 1934-5909

VL - 28

SP - 685-701.e7

JO - Cell Stem Cell

JF - Cell Stem Cell

IS - 4

ER -

Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity

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