@article{3a4fb756d92a404e9379206ab4459d3b,
title = "Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy",
abstract = "Zhao et al. show that in the context of obesity, partial leptin reduction restores hypothalamic leptin sensitivity and leads to reduced food intake, increased energy expenditure, and improved insulin sensitivity. Thus, strategies aimed at partially reducing circulating leptin may represent a promising approach for the treatment of obesity and diabetes.",
keywords = "diabetes, hypothalamus, leptin, leptin resistance, obesity",
author = "Shangang Zhao and Yi Zhu and Schultz, {Robbie D.} and Na Li and Zhenyan He and Zhuzhen Zhang and Alexandre Caron and Qingzhang Zhu and Kai Sun and Wei Xiong and Hui Deng and Jia Sun and Yingfeng Deng and Min Kim and Lee, {Charlotte E.} and Ruth Gordillo and Tiemin Liu and Odle, {Angela K.} and Childs, {Gwen V.} and Ningyan Zhang and Kusminski, {Christine M.} and Elmquist, {Joel K.} and Williams, {Kevin W.} and Zhiqiang An and Scherer, {Philipp E.}",
note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = oct,
day = "1",
doi = "10.1016/j.cmet.2019.08.005",
language = "English (US)",
volume = "30",
pages = "706--719.e6",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "4",
}