Oral ingestion of Ginkgo biloba extract reduces thiobarbituric acid reacting (TBAR) substances in washed platelets of healthy subjects

George B. Kudolo, Wen Wang, Sheryl Dorsey, Janet Blodgett

Producción científica: Articlerevisión exhaustiva

7 Citas (Scopus)

Resumen

Thiobarbituric acid reacting (TBAR) substances were measured in washed platelets before and after ingesting 120 mg of standardized Ginkgo biloba extract daily for 3 months, in both normocholesterolemic (total cholesterol, 160 ± 27 mg/dl; age, 40 ± 13 years; n = 18) and hypercholesterolemic subjects (total cholesterol, 229 ± 35; age, 45 ± 8 years; n = 12). Ginkgo biloba extract significantly reduced cellular content of TBAR substances; 42 ± 21 vs. 28 ± 16 pmol/107 platelets (p < 0.0025) and 50 ± 17 vs. 29 ± 13 pmol/107 platelets (p < 0.004), for the normo- and hypercholemic subjects, respectively. In conclusion, Ginkgo biloba extract is a potent antioxidant in both groups, reducing TBAR substances possibly by inhibiting platelet COX-1 isoform activity.

Idioma originalEnglish (US)
Páginas (desde-hasta)1-15
Número de páginas15
PublicaciónJournal of Herbal Pharmacotherapy
Volumen3
N.º4
DOI
EstadoPublished - 2003

ASJC Scopus subject areas

  • Pharmacology

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