@inbook{89d1d543c8b04ec4b1f6a24e87fa2c01,
title = "Oligo-benzamide-based peptide mimicking tools for modulating biology",
abstract = "The oligo-benzamide scaffold is a rigid organic framework that can hold 2–3 functional groups as O-alkyl substituents on its benzamide units, mirroring their natural arrangement in an α-helix. Oligo-benzamides demonstrated outstanding α-helix mimicry and can be readily synthesized by following high yielding and iterative reaction steps in both solution-phase and solid-phase. A number of oligo-benzamides have been designed to emulate α-helical peptide segments in biologically active proteins and showed strong protein binding, in turn effectively disrupting protein-protein interactions in vitro and in vivo. In this chapter, the design of oligo-benzamides for mimicking α-helices, efficient synthetic routes for producing them, and their biomedical studies showing remarkable potency in inhibiting protein functions are discussed.",
keywords = "LXXLL motif, Nuclear receptor-coregulator interaction, Oligo-benzamides, Peptidomimetics, Prostate and breast cancer, Protein-protein interaction, α-Helix mimetics",
author = "Chen, {Chia Yuan} and Scott Elmore and Ismail Lalami and Henry Neal and Vadlamudi, {Ratna K.} and Raj, {Ganesh V.} and Ahn, {Jung Mo}",
note = "Publisher Copyright: {\textcopyright} 2024",
year = "2024",
month = jan,
doi = "10.1016/bs.mie.2024.04.022",
language = "English (US)",
isbn = "9780443218149",
series = "Methods in Enzymology",
publisher = "Academic Press Inc.",
pages = "221--245",
editor = "David Chenoweth",
booktitle = "Peptide and Peptide Mimicking Tools",
address = "United States",
}