Oligo-benzamide-based peptide mimicking tools for modulating biology

Chia Yuan Chen, Scott Elmore, Ismail Lalami, Henry Neal, Ratna K. Vadlamudi, Ganesh V. Raj, Jung Mo Ahn

Producción científica: Chapter

Resumen

The oligo-benzamide scaffold is a rigid organic framework that can hold 2–3 functional groups as O-alkyl substituents on its benzamide units, mirroring their natural arrangement in an α-helix. Oligo-benzamides demonstrated outstanding α-helix mimicry and can be readily synthesized by following high yielding and iterative reaction steps in both solution-phase and solid-phase. A number of oligo-benzamides have been designed to emulate α-helical peptide segments in biologically active proteins and showed strong protein binding, in turn effectively disrupting protein-protein interactions in vitro and in vivo. In this chapter, the design of oligo-benzamides for mimicking α-helices, efficient synthetic routes for producing them, and their biomedical studies showing remarkable potency in inhibiting protein functions are discussed.

Idioma originalEnglish (US)
Título de la publicación alojadaPeptide and Peptide Mimicking Tools
Subtítulo de la publicación alojadaMethods, Synthesis, Design
EditoresDavid Chenoweth
EditorialAcademic Press Inc.
Páginas221-245
Número de páginas25
ISBN (versión impresa)9780443218149
DOI
EstadoPublished - ene 2024

Serie de la publicación

NombreMethods in Enzymology
Volumen698
ISSN (versión impresa)0076-6879
ISSN (versión digital)1557-7988

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Huella

Profundice en los temas de investigación de 'Oligo-benzamide-based peptide mimicking tools for modulating biology'. En conjunto forman una huella única.

Citar esto