TY - JOUR
T1 - Novel tumor necrosis factor-knockout mice that lack Peyer's patches
AU - Kuprash, Dmitry V.
AU - Tumanov, Alexei V.
AU - Liepinsh, Dmitry J.
AU - Koroleva, Ekaterina P.
AU - Drutskaya, Marina S.
AU - Kruglov, Andrei A.
AU - Shakhov, Alexander N.
AU - Southon, Eileen
AU - Murphy, William J.
AU - Tessarollo, Lino
AU - Grivennikov, Sergei I.
AU - Nedospasov, Sergei A.
PY - 2005/5
Y1 - 2005/5
N2 - We generated a novel tumor necrosis factor (TNF) null mutation using Cre-loxP technology. Mice homozygous for this mutation differ from their "conventional" counterparts; in particular, they completely lack Peyer's patches (PP) but retain all lymph nodes. Our analysis of these novel TNF-knockout mice supports the previously disputed notion of the involvement of TNF-TNFR1 signaling in PP organogenesis. Availability of TNF-knockout strains both with and without PP enables more definitive studies concerning the roles of TNF and PP in various immune functions and disease conditions. Here, we report that systemic ablation of TNF, but not the presence of PP per se, is critical for protection against intestinal Listeria infection in mice.
AB - We generated a novel tumor necrosis factor (TNF) null mutation using Cre-loxP technology. Mice homozygous for this mutation differ from their "conventional" counterparts; in particular, they completely lack Peyer's patches (PP) but retain all lymph nodes. Our analysis of these novel TNF-knockout mice supports the previously disputed notion of the involvement of TNF-TNFR1 signaling in PP organogenesis. Availability of TNF-knockout strains both with and without PP enables more definitive studies concerning the roles of TNF and PP in various immune functions and disease conditions. Here, we report that systemic ablation of TNF, but not the presence of PP per se, is critical for protection against intestinal Listeria infection in mice.
KW - Cytokines
KW - Host defense
KW - Lymphoid organ development
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U2 - 10.1002/eji.200526119
DO - 10.1002/eji.200526119
M3 - Article
C2 - 15832287
AN - SCOPUS:21044457064
SN - 0014-2980
VL - 35
SP - 1592
EP - 1600
JO - European Journal of Immunology
JF - European Journal of Immunology
IS - 5
ER -