Novel Approaches, Drug Candidates, and Targets in Pain Drug Discovery

Samuel Obeng, Takato Hiranita, Francisco León, Lance R. McMahon, Christopher R. McCurdy

Producción científica: Review articlerevisión exhaustiva

37 Citas (Scopus)

Resumen

Because of the problems associated with opioids, drug discovery efforts have been employed to develop opioids with reduced side effects using approaches such as biased opioid agonism, multifunctional opioids, and allosteric modulation of opioid receptors. Receptor targets such as adrenergic, cannabinoid, P2X3 and P2X7, NMDA, serotonin, and sigma, as well as ion channels like the voltage-gated sodium channels Nav1.7 and Nav1.8 have been targeted to develop novel analgesics. Several enzymes, such as soluble epoxide hydrolase, sepiapterin reductase, and MAGL/FAAH, have also been targeted to develop novel analgesics. In this review, old and recent targets involved in pain signaling and compounds acting at these targets are summarized. In addition, strategies employed to reduce side effects, increase potency, and efficacy of opioids are also elaborated. This review should aid in propelling drug discovery efforts to discover novel analgesics.

Idioma originalEnglish (US)
Páginas (desde-hasta)6523-6548
Número de páginas26
PublicaciónJournal of Medicinal Chemistry
Volumen64
N.º10
DOI
EstadoPublished - may 27 2021
Publicado de forma externa

ASJC Scopus subject areas

  • Drug Discovery
  • Molecular Medicine

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