TY - JOUR
T1 - Nosocomial outbreak of Exophiala jeanselmei fungemia associated with contamination of hospital water
AU - Nucci, Marcio
AU - Akiti, Tiyomi
AU - Barreiros, Gloria
AU - Silveira, Fernanda
AU - Revankar, Sanjay G.
AU - Wickes, Brian L.
AU - Sutton, Deanna A.
AU - Patterson, Thomas F.
PY - 2002/6/1
Y1 - 2002/6/1
N2 - From December 1996 through September 1997, we diagnosed 19 cases of fungemia due to Exophiala jeanselmei. We conducted a matched case-control study in which we cultured specimens of blood products, intravenous solutions, and water from a hospital water system. Isolates from environmental cultures were compared to those recovered from patients by random amplification of polymorphic DNA (RAPD). Multivariate analysis showed that neutropenia, longer duration of hospitalization, and use of corticosteroids were risk factors for infection. Environmental cultures yielded E. jeanselmei from 3 of 85 sources: deionized water from the hospital pharmacy, 1 water tank, and water from a sink in a non-patient care area. Use of deionized pharmacy water to prepare antiseptic solutions was discontinued, and no additional cases of infection occurred. RAPD typing showed that isolates from case patients and isolates from the pharmacy water were highly related, whereas the patterns of isolates recovered from the 2 other sources of water were distinct.
AB - From December 1996 through September 1997, we diagnosed 19 cases of fungemia due to Exophiala jeanselmei. We conducted a matched case-control study in which we cultured specimens of blood products, intravenous solutions, and water from a hospital water system. Isolates from environmental cultures were compared to those recovered from patients by random amplification of polymorphic DNA (RAPD). Multivariate analysis showed that neutropenia, longer duration of hospitalization, and use of corticosteroids were risk factors for infection. Environmental cultures yielded E. jeanselmei from 3 of 85 sources: deionized water from the hospital pharmacy, 1 water tank, and water from a sink in a non-patient care area. Use of deionized pharmacy water to prepare antiseptic solutions was discontinued, and no additional cases of infection occurred. RAPD typing showed that isolates from case patients and isolates from the pharmacy water were highly related, whereas the patterns of isolates recovered from the 2 other sources of water were distinct.
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U2 - 10.1086/340344
DO - 10.1086/340344
M3 - Article
C2 - 12015694
AN - SCOPUS:0036604094
SN - 1058-4838
VL - 34
SP - 1475
EP - 1480
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 11
ER -